Marseillevirus Adenitis in an 11-Month-Old Child

被引：37
作者：
Popgeorgiev, Nikolay [1 ]
Michel, Gerard [2 ]
Lepidi, Hubert [2 ]
Raoult, Didier [1 ]
Desnues, Christelle [1 ]
机构：
[1] Aix Marseille Univ, Unite Rech Malad Infect & Trop Emergentes, Fac Med, CNRS,UMR 7278,IRD 198, Marseille, France
[2] CHU La Timone Enfants, Serv Hematol Oncol Pediat, Marseille, France
来源：
JOURNAL OF CLINICAL MICROBIOLOGY | 2013年 / 51卷 / 12期
基金：
欧洲研究理事会;
关键词：
HUMANS;
D O I：
10.1128/JCM.01918-13
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
A Marseillevirus (giant virus of amoeba) has been found in the blood and stool samples of individuals who otherwise appear to be healthy. During an attempt to define a serological cutoff for Marseillevirus by enzyme-linked immunosorbent assay (ELISA) in children, we serendipitously detected high antibody responses to Marseillevirus in an 11-month-old boy suffering from adenitis. Marseillevirus DNA was then found in his blood using PCR and with a unique sequence. We identified Marseillevirus in a lymph node using fluorescence in situ hybridization (FISH) and immunohistochemistry, and the lymph node was removed surgically. The child was declared to be cured 1 year later. We conclude that adenitis during early childhood may be caused by Marseillevirus.
引用
收藏
页码：4102 / 4105
页数：4
相关论文
共 8 条
[1]   Giant Marseillevirus highlights the role of amoebae as a melting pot in emergence of chimeric microorganisms [J].
Boyer, Mickael ;
Yutin, Natalya ;
Pagnier, Isabelle ;
Barrassi, Lina ;
Fournous, Ghislain ;
Espinosa, Leon ;
Robert, Catherine ;
Azza, Said ;
Sun, Siyang ;
Rossmann, Michael G. ;
Suzan-Monti, Marie ;
La Scola, Bernard ;
Koonin, Eugene V. ;
Raoult, Didier .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (51) :21848-21853
[2]   Evidence of the megavirome in humans [J].
Colson, Philippe ;
Fancello, Laura ;
Gimenez, Gregory ;
Armougom, Fabrice ;
Desnues, Christelle ;
Fournous, Ghislain ;
Yoosuf, Niyaz ;
Million, Matthieu ;
La Scola, Bernard ;
Raoult, Didier .
JOURNAL OF CLINICAL VIROLOGY, 2013, 57 (03) :191-200
[3]   Reclassification of Giant Viruses Composing a Fourth Domain of Life in the New Order Megavirales [J].
Colson, Philippe ;
de Lamballerie, Xavier ;
Fournous, Ghislain ;
Raoult, Didier .
INTERVIROLOGY, 2012, 55 (05) :321-332
[4]   Microbial culturomics: paradigm shift in the human gut microbiome study [J].
Lagier, J. -C. ;
Armougom, F. ;
Million, M. ;
Hugon, P. ;
Pagnier, I. ;
Robert, C. ;
Bittar, F. ;
Fournous, G. ;
Gimenez, G. ;
Maraninchi, M. ;
Trape, J. -F. ;
Koonin, E. V. ;
La Scola, B. ;
Raoult, D. .
CLINICAL MICROBIOLOGY AND INFECTION, 2012, 18 (12) :1185-1193
[5]   Marseillevirus-Like Virus Recovered From Blood Donated by Asymptomatic Humans [J].
Popgeorgiev, Nikolay ;
Boyer, Mickael ;
Fancello, Laura ;
Monteil, Sonia ;
Robert, Catherine ;
Rivet, Romain ;
Nappez, Claude ;
Azza, Said ;
Chiaroni, Jacques ;
Raoult, Didier ;
Desnues, Christelle .
JOURNAL OF INFECTIOUS DISEASES, 2013, 208 (07) :1042-1050
[6]   Lymph node biopsy specimens and diagnosis of cat-scratch disease [J].
Rolain, Jean-Marc ;
Lepidi, Hubert ;
Zanaret, Michel ;
Triglia, Jean-Michel ;
Michel, Gerard ;
Thomas, Pascal-Alexandre ;
Texereau, Michele ;
Stein, Andreas ;
Romaru, Anette ;
Eb, Francois ;
Raoult, Didier .
EMERGING INFECTIOUS DISEASES, 2006, 12 (09) :1338-1344
[7]   First Isolation of Mimivirus in a Patient With Pneumonia [J].
Saadi, Hanene ;
Pagnier, Isabelle ;
Colson, Philippe ;
Cherif, Jouda Kanoun ;
Beji, Majed ;
Boughalmi, Mondher ;
Azza, Said ;
Armstrong, Nicholas ;
Robert, Catherine ;
Fournous, Ghislain ;
La Scola, Bernard ;
Raoult, Didier .
CLINICAL INFECTIOUS DISEASES, 2013, 57 (04) :E127-E134
[8]   Lausannevirus, a giant amoebal virus encoding histone doublets [J].
Thomas, Vincent ;
Bertelli, Claire ;
Collyn, Francois ;
Casson, Nicola ;
Telenti, Amalio ;
Goesmann, Alexander ;
Croxatto, Antony ;
Greub, Gilbert .
ENVIRONMENTAL MICROBIOLOGY, 2011, 13 (06) :1454-1466
1