Novel Strategy for Synthesis of Substituted Benzimidazo[1,2-a]quinolines

被引：53

作者：

Kato, Jun-ya ^{[1
]}

Ito, Yutaro ^{[1
]}

Ijuin, Ryosuke ^{[1
]}

Aoyama, Hiroshi ^{[1
]}

Yokomatsu, Tsutomu ^{[1
]}

机构：

[1] Tokyo Univ Pharm & Life Sci, Sch Pharm, Hachioji, Tokyo 1920392, Japan

来源：

ORGANIC LETTERS | 2013年 / 15卷 / 14期

关键词：

EFFICIENT ROUTE; N-ARYLATION; DNA-BINDING; DERIVATIVES; AMINATION; PART;

D O I：

10.1021/ol4017723

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient method for the synthesis of benzimidazo[1,2-a]quinolines under transition-metal-free conditions has been developed through a cascade reaction involving sequential aromatic nucleophilic substitution and intramolecular Knoevenagel condensation reactions. This method is applicable for the synthesis of a wide range of benzimidazo[1,2-a]quinoline derivatives from readily available 2-fluoroarylaldehyde and benzimidazole substrates.

引用

页码：3794 / 3797

页数：4

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