The effects of opiate consumption on serum reproductive hormone levels, sperm parameters, seminal plasma antioxidant capacity and sperm DNA integrity

被引：54

作者：

Safarinejad, Mohammad Reza ^{[1
,2
]}

Asgari, Seyyed Alaeddin ^{[3
]}

Farshi, Alireza ^{[4
]}

Ghaedi, Gholamhossein ^{[5
]}

Kolahi, Ali Asghar ^{[6
]}

Iravani, Shahrokh ^{[7
]}

Khoshdel, Ali Reza ^{[8
]}

机构：

[1] Clin Ctr Urol Dis Diag, Tehran, Iran

[2] Private Clin Specialized Urol & Androl Genet, Tehran, Iran

[3] Guilan Univ Med Sci, Urol Res Ctr, Rasht, Iran

[4] Tabriz Univ Med Sci, Dept Urol, Tabriz, Iran

[5] Shahed Univ, Fac Med, Dept Psychiat, Tehran, Iran

[6] Shahid Beheshti Univ Med Sci, Dept Hlth & Community Med, Tehran, Iran

[7] Aja Univ Med Sci, Fac Med, Dept Biotechnol, Res Ctr, Tehran, Iran

[8] Aja Univ Med Sci, Fac Med, Dept Clin Epidemiol, Res Ctr, Tehran, Iran

来源：

REPRODUCTIVE TOXICOLOGY | 2013年 / 36卷

关键词：

Dugs; Addiction; Male infertility; Substance abuse; Acrosome reaction; DNA fragmentation; OXIDATIVE STRESS; MALE-FERTILITY; INFERTILITY; DAMAGE; RISK; MEN; ABNORMALITIES; SPERMATOZOA; ADDICT; HEROIN;

D O I：

10.1016/j.reprotox.2012.11.010

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We evaluated the effects of opiate consumption on semen quality, sperm function, seminal plasma antioxidant capacity, and sperm DNA integrity. A total of 142 opiate addict men (group 1) were enrolled in the study and 146 healthy age matched male volunteers (group 2) served as controls. Two semen analyses were performed in all participants. Sperm chromatin structure assay (SCSA) was used to identify sperm DNA integrity. The mean +/- SD sperm concentration in opiate users and in control subjects was 22.2 +/- 4.4 and 66.3 +/- 8.3 million per ml, respectively (P = 0.002). A significant increase in the amount of fragmented DNA was found in opiate consumers compared with that in controls (36.4 +/- 3.8% vs. 27.1 +/- 2.4%, P = 0.004). Significantly decreased levels of catalase-like and superoxide dismutase-like (SOD) activity were observed in group 1 compared with group 2. Opiate consumption has significant adverse effects on semen quality. In cases of unexplained infertility in men, opium consumption should be considered as a possible factor. (c) 2012 Elsevier Inc. All rights reserved.

引用

页码：18 / 23

页数：6

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