Avermectin/polyacrylate nanoparticles: preparation, characterization, anti-UV and sustained release properties

被引：5
作者：
Lin, Guan-Quan [1 ,2 ]
Chen, Hua-Yao [1 ,2 ]
Zhou, Hong-Jun [1 ,2 ]
Zhou, Xin-Hua [1 ,2 ]
Xu, Hua [1 ,2 ]
机构：
[1] Zhongkai Univ Agr & Engn, Sch Chem & Chem Engn, Guangzhou, Guangdong, Peoples R China
[2] Guangzhou Key Lab Efficient Use Agr Chem, Guangzhou, Guangdong, Peoples R China
来源：
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS | 2019年 / 68卷 / 10期
基金：
中国国家自然科学基金;
关键词：
Anti-UV; avermectin; nanoparticles; polyacrylic ester; self-assembly; sustained-release; AVERMECTIN MICROCAPSULES; DRUG-DELIVERY; SLOW-RELEASE; PERFORMANCE; SURFACE; DEGRADATION; ENVIRONMENT; ABSORPTION; COPOLYMERS; POLYMERS;
D O I：
10.1080/00914037.2018.1473866
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
In an effort to reduce the dose of drugs and in order to improve drug efficacy, avermectin (AVM) was encapsulated by amphipathic polyacrylic ester (PAE) via self-assembly. The experimental results indicated that the AVM/PAE nanoparticles were spherical in shape, homogeneous dispersion, and had a core-shell structure, the particle size ranged from 172.7 nm to 337.8 nm, the highest encapsulation efficiency and loading capacity were 62.11 and 25.65%. The anti-UV property has been significantly improved. Consistent with the Korsmeyer-Peppas model, the release rate was observed to be higher upon decreasing Tg and increasing the core-shell ratio.
引用
收藏
页码：582 / 589
页数：8
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