In Vitro Activities of Miltefosine and Antibacterial Agents from the Macrolide, Oxazolidinone, and Pleuromutilin Classes against Pythium insidiosum and Pythium aphanidermatum

被引：0
作者：
Loreto, Erico S. [1 ,3 ]
Tondolo, Juliana S. M. [2 ]
Oliveira, Daniele C. [3 ]
Santurio, Janio M. [2 ]
Alves, Sydney H. [1 ]
机构：
[1] Univ Fed Santa Maria, Dept Microbiol & Parasitol, Ctr Ciencias Saude, Programa Posgrad Ciencias Farmaceut, Santa Maria, RS, Brazil
[2] Univ Fed Santa Maria, Dept Microbiol & Parasitol, Ctr Ciencias Saude, Programa Posgrad Farmacol, Santa Maria, RS, Brazil
[3] Sobresp Fac Ciencias Saude, Santa Maria, RS, Brazil
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2018年 / 62卷 / 03期
关键词：
pythiosis; susceptibility; treatment; oomycetes; CANDIDA-ALBICANS; AMPHOTERICIN-B; SUSCEPTIBILITY; COMBINATION; AZITHROMYCIN; VORICONAZOLE; MINOCYCLINE; MODEL; CLARITHROMYCIN; TIGECYCLINE;
D O I：
10.1128/AAC.01678-17
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
We tested 29 isolates of Pythium insidiosum and one isolate of Pythium aphanidermatum to investigate their susceptibility to miltefosine and antibacterial drugs from the macrolide, oxazolidinone, and pleuromutilin classes. We found that miltefosine, azithromycin, clarithromycin, josamycin, linezolid, sutezolid, retapamulin, tiamulin, and valnemulin had inhibitory and cidal activity against the pathogens at concentrations ranging from 0.25 to 64 mu g/ml. Our results suggest that these antimicrobials are promising candidates for future studies on pythiosis in animals and humans.
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页数：6
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