AED Treatment Through Different Ages: As Our Brains Change, Should Our Drug Choices Also?

被引:28
作者
French, Jacqueline A. [1 ]
Staley, Brigid A. [1 ]
机构
[1] NYU, Dept Neurol, Sch Med, New York, NY 10016 USA
关键词
TECHNOLOGY-ASSESSMENT SUBCOMMITTEE; QUALITY STANDARDS SUBCOMMITTEE; ANTIEPILEPTIC DRUGS; AMERICAN ACADEMY; NEONATAL SEIZURES; VALPROIC ACID; EPILEPSY; THERAPEUTICS; PREGNANCY; PHENYTOIN;
D O I
10.5698/1535-7511-12.4s.22
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Patient age can impact selection of the optimal antiepileptic drug for a number of reasons. Changes in brain physiology from neonate to elderly, as well as changes in underlying etiologies of epilepsy, could potentially affect the ability of different drugs to control seizures. Unfortunately, much of this is speculative, as good studies demonstrating differences in efficacy across age ranges do not exist. Beyond the issue of efficacy, certain drugs may be more or less appropriate at different ages because of differing pharmacokinetics, including changes in hepatic metabolism, absorption, and elimination. Lack of appropriate drug formulations (such as liquid forms) may be a barrier to using drugs in the very young. Finally, some serious adverse events are seen either exclusively or preferentially at different ages.
引用
收藏
页码:22 / 27
页数:6
相关论文
共 35 条
[1]   Variability of total phenytoin serum concentrations within elderly nursing home residents [J].
Birnbaum, A ;
Hardie, NA ;
Leppik, IE ;
Conway, JM ;
Bowers, SE ;
Lackner, T ;
Graves, NM .
NEUROLOGY, 2003, 60 (04) :555-559
[2]   Population pharmacokinetics of valproic acid concentrations in elderly nursing home residents [J].
Birnbaum, Angela K. ;
Ahn, Jae Eun ;
Brundage, Richard C. ;
Hardie, Nancy A. ;
Conway, Jeannine M. ;
Leppik, Ilo E. .
THERAPEUTIC DRUG MONITORING, 2007, 29 (05) :571-575
[3]   Epilepsy in later life [J].
Brodie, Martin J. ;
Elder, Andrew T. ;
Kwan, Patrick .
LANCET NEUROLOGY, 2009, 8 (11) :1019-1030
[4]   Vigabatrin in the treatment of childhood epilepsy: A retrospective chart review of efficacy and safety profile [J].
Camposano, Susana E. ;
Major, Philippe ;
Halpern, Elkan ;
Thiele, Elizabeth A. .
EPILEPSIA, 2008, 49 (07) :1186-1191
[5]   Drug treatment of neonatal seizures by neonatologists and paediatric neurologists [J].
Carmo, KB ;
Barr, P .
JOURNAL OF PAEDIATRICS AND CHILD HEALTH, 2005, 41 (07) :313-316
[6]   Single episode of neonatal seizures permanently alters glutamatergic synapses [J].
Cornejo, Brandon J. ;
Mesches, Michael H. ;
Coultrap, Steven ;
Browning, Michael D. ;
Benke, Timothy A. .
ANNALS OF NEUROLOGY, 2007, 61 (05) :411-426
[7]  
European Medicines Agency, GUID CLIN INV MED PL
[8]   Age-dependent seizure semiology in temporal lobe epilepsy [J].
Fogarasi, Andras ;
Tuxhorn, Ingrid ;
Janszky, Jozsef ;
Janszky, Imre ;
Rasonyi, Gyorgy ;
Kelemen, Anna ;
Halasz, Peter .
EPILEPSIA, 2007, 48 (09) :1697-1702
[9]   Efficacy and tolerability of the new antiepileptic drugs I: Treatment of new onset epilepsy - Report of the Therapeutics and Technology Assessment Subcommittee and Quality Standards Subcommittee of the American Academy of Neurology and the American Epilepsy Society [J].
French, JA ;
Kanner, AM ;
Bautista, J ;
Abou-Khalil, B ;
Browne, T ;
Harden, CL ;
Theodore, WH ;
Bazil, C ;
Stern, J ;
Schachter, SC ;
Bergen, D ;
Hirtz, D ;
Montouris, GD ;
Nespeca, M ;
Gidal, B ;
Marks, WJ ;
Turk, WR ;
Fischer, JH ;
Bourgeois, B ;
Wilner, A ;
Faught, RE ;
Sachdeo, RC ;
Beydoun, A ;
Glauser, TA .
NEUROLOGY, 2004, 62 (08) :1252-1260
[10]  
French JA, 2004, NEUROLOGY, V62, P1261, DOI 10.1212/01.WNL.0000123695.22623.32