Inhibitors of MAO-B and COMT: their effects on brain dopamine levels and uses in Parkinson's disease

被引：76
作者：
Finberg, John P. M. [1 ]
机构：
[1] Rappaport Fac Med, Neurosci Grp, Haifa, Israel
来源：
JOURNAL OF NEURAL TRANSMISSION | 2019年 / 126卷 / 04期
关键词：
MAO-B; COMT; L-DOPA; Dopamine synthesis; Dyskinesia; CATECHOL-O-METHYLTRANSFERASE; MONOAMINE-OXIDASE-B; DELAYED-START TRIAL; POST-HOC ANALYSES; DOUBLE-BLIND; MOTOR FLUCTUATIONS; SELECTIVE-INHIBITION; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE; NEUROPROTECTIVE MECHANISM; LEVODOPA PHARMACOKINETICS;
D O I：
10.1007/s00702-018-1952-7
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
MAO-B and COMT are both enzymes involved in dopamine breakdown and metabolism. Inhibitors of these enzymes are used in the treatment of Parkinson's disease. This review article describes the scientific background to the localization and function of the enzymes, the physiological changes resulting from their inhibition, and the basic and clinical pharmacology of the various inhibitors and their role in treatment of Parkinson's disease.
引用
收藏
页码：433 / 448
页数：16
相关论文
共 148 条
[1]   EFFECTS OF L-DOPA ON EXTRACELLULAR DOPAMINE IN STRIATUM OF NORMAL AND 6-HYDROXYDOPAMINE-TREATED RATS [J].
ABERCROMBIE, ED ;
BONATZ, AE ;
ZIGMOND, MJ .
BRAIN RESEARCH, 1990, 525 (01) :36-44
[2]   INCREASED ACTIVITY OF BRAIN AND PLATELET MONOAMINE-OXIDASE IN DEMENTIA OF ALZHEIMER TYPE [J].
ADOLFSSON, R ;
GOTTFRIES, CG ;
ORELAND, L ;
WIBERG, A ;
WINBLAD, B .
LIFE SCIENCES, 1980, 27 (12) :1029-1034
[3]   Alterations in striatal oxidative stress level produced by pharmacological manipulation of dopamine as shown by a novel synthetic marker molecule [J].
Aluf, Y. ;
Vaya, J. ;
Khatib, S. ;
Finberg, J. P. M. .
NEUROPHARMACOLOGY, 2011, 61 (1-2) :87-94
[4]   Selective inhibition of monoamine oxidase A or B reduces striatal oxidative stress in rats with partial depletion of the nigro-striatal dopaminergic pathway [J].
Aluf, Yuval ;
Vaya, Jacob ;
Khatib, Soliman ;
Loboda, Yelena ;
Finberg, John P. M. .
NEUROPHARMACOLOGY, 2013, 65 :48-57
[5]   Tolcapone improves cognition and cortical information processing in normal human subjects [J].
Apud, Jose A. ;
Mattay, Venkata ;
Chen, Jingshan ;
Kolachana, Bhaskar S. ;
Callicott, Joseph H. ;
Rasetti, Roberta ;
Alce, Guilna ;
Iudicello, Jennifer E. ;
Akbar, Natkai ;
Egan, Michael F. ;
Goldberg, Terry E. ;
Weinberger, Daniel R. .
NEUROPSYCHOPHARMACOLOGY, 2007, 32 (05) :1011-1020
[6]   Dopamine- or L-DOPA-induced neurotoxicity: The role of dopamine quinone formation and tyrosinase in a model of Parkinson's disease [J].
Asanuma, M ;
Miyazaki, I ;
Ogawa, N .
NEUROTOXICITY RESEARCH, 2003, 5 (03) :165-176
[7]   Striatal Astrocytes Act as a Reservoir for L-DOPA [J].
Asanuma, Masato ;
Miyazaki, Ikuko ;
Murakami, Shinki ;
Diaz-Corrales, Francisco J. ;
Ogawa, Norio .
PLOS ONE, 2014, 9 (09)
[8]   Contrasting neuroprotective and neurotoxic actions of respective metabolites of anti-Parkinson drugs rasagiline and selegiline [J].
Bar Am, O ;
Amit, T ;
Youdim, MBH .
NEUROSCIENCE LETTERS, 2004, 355 (03) :169-172
[9]   Cardiovascular baroreceptor activity and selective inhibition of monoamine oxidase [J].
Bar-Am, Orit ;
Gross, Aviva ;
Friedman, Rachel ;
Finberg, John P. M. .
EUROPEAN JOURNAL OF PHARMACOLOGY, 2012, 683 (1-3) :226-230
[10]   The neuroprotective mechanism of 1-(R)-aminoindan, the major metabolite of the anti-parkinsonian drug rasagiline [J].
Bar-Am, Orit ;
Weinreb, Orly ;
Amit, Tamar ;
Youdim, Moussa B. H. .
JOURNAL OF NEUROCHEMISTRY, 2010, 112 (05) :1131-1137
12345678910