High pressure mediated asymmetric Henry reaction of nitromethane with carbonyl compounds catalyzed by cinchona alkaloids

被引：0

作者：

Misumi, Y ^{[1
]}

Bulman, RA

Matsumoto, K

机构：

[1] Kyoto Univ, Grad Sch Human & Environm Studies, Kyoto 6068501, Japan

[2] Natl Radiol Protect Board, Didcot OX11 0RQ, Oxon, England

来源：

HETEROCYCLES | 2002年 / 56卷 / 1-2期

关键词：

Henry reaction; asymmetric reaction; high pressure effect; nitro alcohol; cinchona alkaloid;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Asymmetric nitroaldol reactions, catalyzed by cinchona alkaloid, of nitromethane have been investigated. High pressure played an interesting role in the overall reactions that form beta-nitro alcohols. From the enantiomeric states of the products formed under different reaction conditions, we deduce that the nature of transition termolecular species formed by the carbonyl compounds with quinidine or quinine determines the stereoselective outcome of the reaction under high pressure.

引用

页码：599 / 605

页数：7

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