The effects of MDMA on socio-emotional processing: Does MDMA differ from other stimulants?

被引:77
作者
Bershad, Anya K. [1 ,2 ]
Miller, Melissa A. [1 ]
Baggott, Matthew J. [3 ]
de Wit, Harriet [1 ]
机构
[1] Univ Chicago, Dept Psychiat & Behav Neurosci, 5841 S Maryland Ave MC3077, Chicago, IL 60637 USA
[2] Univ Chicago, Interdisciplinary Scientist Training Program, Chicago, IL 60637 USA
[3] Genentech Inc, People Analyt, San Francisco, CA USA
关键词
MDMA; social behavior; stimulants; amphetamines; emotion; POSTTRAUMATIC-STRESS-DISORDER; HUMAN SEXUAL FUNCTION; D-AMPHETAMINE; 3,4-METHYLENEDIOXYMETHAMPHETAMINE MDMA; HEALTHY-VOLUNTEERS; SEROTONIN TRANSPORTERS; INTRANASAL OXYTOCIN; PROSOCIAL FEELINGS; ASPERGER-SYNDROME; SOCIAL COGNITION;
D O I
10.1177/0269881116663120
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
+/- 3,4-Methylenedioxymethamphetamine (MDMA) is a popular recreational drug that enhances sociability and feelings of closeness with others. These prosocial effects appear to motivate the recreational use of MDMA and may also form the basis of its potential as an adjunct to psychotherapy. However, the extent to which MDMA differs from prototypic stimulant drugs, such as dextroamphetamine, methamphetamine, and methylphenidate, in either its behavioral effects or mechanisms of action, is not fully known. The purpose of this review is to evaluate human laboratory findings of the social effects of MDMA compared to other stimulants, ranging from simple subjective ratings of sociability to more complex elements of social processing and behavior. We also review the neurochemical mechanisms by which these drugs may impact sociability. Together, the findings reviewed here lay the groundwork for better understanding the socially enhancing effects of MDMA that distinguish it from other stimulant drugs, especially as these effects relate to the reinforcing and potentially therapeutic effects of the drug.
引用
收藏
页码:1248 / 1258
页数:11
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