Targeting cancer stem cells and signaling pathways by resveratrol and pterostilbene

被引：50

作者：

Zhang, Lingling ^{[1
,2
,3
,4
,5
]}

Wen, Xiang ^{[1
]}

Li, Mengmeng ^{[1
]}

Li, Shiming ^{[2
]}

Zhao, Hui ^{[1
]}

机构：

[1] Tianjin Univ Commerce, Sch Biotechnol & Food Sci, Food Sci Div, Tianjin Key Lab Food & Biotechnol, Tianjin, Peoples R China

[2] Huanggang Normal Univ, Food Sci Div, Hubei Key Lab Econ Forest Germplasm Improvement &, Huanggang, Hubei, Peoples R China

[3] Shanghai Inst Planned Parenthood Res, Dept Pharmacol & Toxicol, Natl Evaluat Ctr Toxicol Fertil Regulating Drug, Shanghai, Peoples R China

[4] NPFPC Shanghai, Key Lab Reprod Regulat, Shanghai, Peoples R China

[5] Fudan Univ, Reprod & Dev Res Inst, Food Sci Div, Shanghai, Peoples R China

来源：

BIOFACTORS | 2018年 / 44卷 / 01期

基金：

中国国家自然科学基金;

关键词：

resveratrol; ptereostilbene; stem cells; cancer; signaling pathways; ACUTE MYELOID-LEUKEMIA; SELF-RENEWAL; IN-VITRO; PHYTOCHEMICALS; SUPPRESSES; MODULATION; EXPRESSION; GENERATION; CARCINOMA; APOPTOSIS;

D O I：

10.1002/biof.1398

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In past decades, increasing evidence regarding cancer stem cells (CSCs) may account for carcinogenesis, tumor drug-resistant, and metastasis. CSCs are even considered as the root causes of tumor recurrence and metastases. Targeting CSCs may provide a new clue to cure cancer. Epidemiological and clinical studies have suggested that intake of dietary natural products may bring health benefits including lowering risk of cancer incidence. In this review, we have particularly focused on targeting signaling pathways of CSCs by natural resveratrol and its dimethylated derivative pterostilbene. (c) 2017 BioFactors, 44(1):61-68, 2018

引用

页码：61 / 68

页数：8

共 49 条

[1]

Abdul Khalek Feras J, 2010, Gastrointest Cancer Res, pS16

[2]

Bahr C., 2017, EMBO J

[3] Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell [J].

Bonnet, D ;

Dick, JE .

NATURE MEDICINE, 1997, 3 (07) :730-737

[4] Pterostilbene Induces Cell Apoptosis and Cell Cycle Arrest in T-Cell Leukemia/Lymphoma by Suppressing the ERK1/2 Pathway [J].

Chang, Gaomei ;

Xiao, Wenqin ;

Xu, Zhijian ;

Yu, Dandan ;

Li, Bo ;

Zhang, Yong ;

Sun, Xi ;

Xie, Yongsheng ;

Chang, Shuaikang ;

Gao, Lu ;

Chen, Gege ;

Hu, Liangning ;

Xie, Bingqian ;

Dai, Bojie ;

Zhu, Weiliang ;

Shi, Jumei .

BIOMED RESEARCH INTERNATIONAL, 2017, 2017

[5] Resveratrol Inhibits Alpha-Melanocyte-Stimulating Hormone Signaling, Viability, and Invasiveness in Melanoma Cells [J].

Chen, Yu-Jen ;

Chen, Ying-Yin ;

Lin, Yi-Feng ;

Hu, Hsuan-Yun ;

Liao, Hui-Fen .

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2013, 2013

[6] The resveratrol analog HS-1793 enhances radiosensitivity of mouse-derived breast cancer cells under hypoxic conditions [J].

Choi, Yoo Jin ;

Heo, Kyu ;

Park, Hee Sung ;

Yang, Kwang Mo ;

Jeong, Min Ho .

INTERNATIONAL JOURNAL OF ONCOLOGY, 2016, 49 (04) :1479-1488

[7] Resveratrol Impairs Glioma Stem Cells Proliferation and Motility by Modulating the Wnt Signaling Pathway [J].

Cilibrasi, Chiara ;

Riva, Gabriele ;

Romano, Gabriele ;

Cadamuro, Massimiliano ;

Bazzoni, Riccardo ;

Butta, Valentina ;

Paoletta, Laura ;

Dalpra, Leda ;

Strazzabosco, Mario ;

Lavitrano, Marialuisa ;

Giovannoni, Roberto ;

Bentivegna, Angela .

PLOS ONE, 2017, 12 (01)

[8] Selective elimination of leukemia stem cells: Hitting a moving target [J].

Crews, Leslie A. ;

Jamieson, Catriona H. M. .

CANCER LETTERS, 2013, 338 (01) :15-22

[9] Targeting cancer stem cells and signaling pathways by phytochemicals: Novel approach for breast cancer therapy [J].

Dandawate, Prasad R. ;

Subramaniam, Dharmalingam ;

Jensen, Roy A. ;

Anant, Shrikant .

SEMINARS IN CANCER BIOLOGY, 2016, 40-41 :192-208

[10]

Debnath T, 2017, FOOD FUNCT, V8, P3432, DOI [10.1039/C7FO00739F, 10.1039/c7fo00739f]

← 1 2 3 4 5 →