A dynamic reversible RNA N6-methyladenosine modification: current status and perspectives

被引：119

作者：

Bi, Zhen ^{[1
]}

Liu, Youhua ^{[1
]}

Zhao, Yuanling ^{[1
]}

Yao, Yongxi ^{[1
]}

Wu, Ruifan ^{[1
]}

Liu, Qing ^{[1
]}

Wang, Yizhen ^{[1
]}

Wang, Xinxia ^{[1
]}

机构：

[1] Zhejiang Univ, Coll Anim Sci, Key Lab Anim Nutr & Feed Sci, Minist Agr,Zhejiang Prov Lab Feed & Anim Nutr, 866 Yuhangtang Rd, Hangzhou, Zhejiang, Peoples R China

来源：

JOURNAL OF CELLULAR PHYSIOLOGY | 2019年 / 234卷 / 06期

基金：

中国国家自然科学基金;

关键词：

demethylases; m(6)A; methyltransferases; mRNA methylation; PRE-MESSENGER-RNAS; NUCLEAR-RNA; M(6)A RNA; YTH DOMAIN; FTO GENE; REGULATES ADIPOGENESIS; PARTIAL-PURIFICATION; STRUCTURAL BASIS; SELF-RENEWAL; DNA-DAMAGE;

D O I：

10.1002/jcp.28014

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

N-6-methyladenosine (m(6)A), as the most abundant RNA epigenetic modifications, has been shown to play critical roles in various biological functions. Research about enzymes that can catalyze and remove m(6)A have revealed its comprehensive roles in messenger RNA (mRNA) metabolism and other physiological processes. The "readers" including YTH domain-containing proteins, hnRNPC, hnRNPG, hnRNPA2B1, IGF2BP1, IGF2BP2, and IGF2BP3, which can affect the fates of mRNA in an m(6)A-dependent manner. In this review, we focus on recent advances in the research of the m(6)A modifications, especially about the latest functions of its writers, erasers, readers in RNA metabolism, cancer, and lipid metabolism. In the end, we provide insights into the underlying molecular mechanisms of m(6)A modifications.

引用

页码：7948 / 7956

页数：9

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