A Novel 5-Fluorouracil-loaded Polyelectrolyte Nanoparticle Formulation

被引：0

作者：

Fan, Yuling ^{[1
]}

Fan, Bingyu ^{[1
]}

Li, Qiang ^{[2
]}

Leng, Shuang ^{[3
]}

Ma, Lihua ^{[3
]}

机构：

[1] Harbin Univ Commerce, Res Ctr Life Sci & Environm Sci, Harbin 150076, Peoples R China

[2] Heilongjiang Univ, Sch Chem & Mat Sci, Harbin 150080, Peoples R China

[3] Harbin Univ Commerce, Natl Minsit Educ, Antitumor Nat Med Engn Res Ctr, Harbin 150076, Peoples R China

来源：

MATERIAL DESIGN, PROCESSING AND APPLICATIONS, PARTS 1-4 | 2013年 / 690-693卷

关键词：

5-Fluorouracil; Polyelectrolyte Nanoparticles;

D O I：

10.4028/www.scientific.net/AMR.690-693.518

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

To successfully prepare drug delivery system, nanoparticles (NPs) with simple and effective method avoiding use of potentially toxic solvent and components, 5-fluorouracil (5-Fu) was chosen as a model low molecular weight chemotherapeutic drug and 5-Fu- loaded NPs were prepared with the lecithin emulsified method following the alginate solidification and chitosan aggregation. Prescription was optimized by orthogonal experiment. The resultant 5-Fu NPs had a spherical structure with a diameter about 200 nm. The encapsulation efficiency of 5-Fu NPs is 55.36 +/- 1.10%. The loading capacity is 4.22 +/- 0.14%.

引用

页码：518 / +

页数：2

共 12 条

[1]

Ahmad Z, 2008, EXPERT OPIN DRUG DEL, V5, P1323, DOI [10.1517/17425240802600662, 10.1517/17425240802600662 ]

[2]

Davidson JM., 2007, PHARM RES, V24, P98

[3]

Delpino CJ., 2005, CLIN TRANSL ONCOL, V7, P6

[4] 5-Fluorouracil: forty-plus and still ticking. A review of its preclinical and clinical development [J].

Grem, JL .

INVESTIGATIONAL NEW DRUGS, 2000, 18 (04) :299-313

[5] Chitosan Based Polyelectrolyte Complexes as Potential Carrier Materials in Drug Delivery Systems [J].

Hamman, Josias H. .

MARINE DRUGS, 2010, 8 (04) :1305-1322

[6] Nanoparticles: pharmacological and toxicological significance [J].

Medina, C. ;

Santos-Martinez, M. J. ;

Radomski, A. ;

Corrigan, O. I. ;

Radomski, M. W. .

BRITISH JOURNAL OF PHARMACOLOGY, 2007, 150 (05) :552-558

[7]

Nagpal K., 2010, CHEM PHARM BULL, V58, P3

[8] Biological evaluation of 5-fluorouracil nanoparticles for cancer chemotherapy and its dependence on the carrier, PLGA [J].

Nair, Lekha K. ;

Jagadeeshan, Sankar ;

Nair, S. Asha ;

Kumar, G. S. Vinod .

INTERNATIONAL JOURNAL OF NANOMEDICINE, 2011, 6 :1685-1697

[9] Review and current status of emulsion/dispersion technology using an internal gelation process for the design of alginate particles [J].

Reis, Catarina P. ;

Neufeld, Ronald J. ;

Vilela, Sandra ;

Ribeiro, Antonio J. ;

Veiga, Francisco .

JOURNAL OF MICROENCAPSULATION, 2006, 23 (03) :245-257

[10] Advances of Cancer Therapy by Nanotechnology [J].

Wang, Xu ;

Wang, Yiqing ;

Chen, Zhuo ;

Shin, Dong M. .

CANCER RESEARCH AND TREATMENT, 2009, 41 (01) :1-11

← 1 2 →