A Novel 5-Fluorouracil-loaded Polyelectrolyte Nanoparticle Formulation

被引：0

作者：

Fan, Yuling ^{[1
]}

Fan, Bingyu ^{[1
]}

Li, Qiang ^{[2
]}

Leng, Shuang ^{[3
]}

Ma, Lihua ^{[3
]}

机构：

[1] Harbin Univ Commerce, Res Ctr Life Sci & Environm Sci, Harbin 150076, Peoples R China

[2] Heilongjiang Univ, Sch Chem & Mat Sci, Harbin 150080, Peoples R China

[3] Harbin Univ Commerce, Natl Minsit Educ, Antitumor Nat Med Engn Res Ctr, Harbin 150076, Peoples R China

来源：

MATERIAL DESIGN, PROCESSING AND APPLICATIONS, PARTS 1-4 | 2013年 / 690-693卷

关键词：

5-Fluorouracil; Polyelectrolyte Nanoparticles;

D O I：

10.4028/www.scientific.net/AMR.690-693.518

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

To successfully prepare drug delivery system, nanoparticles (NPs) with simple and effective method avoiding use of potentially toxic solvent and components, 5-fluorouracil (5-Fu) was chosen as a model low molecular weight chemotherapeutic drug and 5-Fu- loaded NPs were prepared with the lecithin emulsified method following the alginate solidification and chitosan aggregation. Prescription was optimized by orthogonal experiment. The resultant 5-Fu NPs had a spherical structure with a diameter about 200 nm. The encapsulation efficiency of 5-Fu NPs is 55.36 +/- 1.10%. The loading capacity is 4.22 +/- 0.14%.

引用

页码：518 / +

页数：2

共 12 条

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