The Estonian H1N1 influenza 2009 outbreak was highly underestimated

被引：1

作者：

Saar, Regina ^{[1
]}

Podersoo, Diivi ^{[2
]}

Jaervelaid, Mari ^{[3
]}

Tuubel, Linda ^{[4
]}

Suurvaeli, Jaanus ^{[1
]}

Nutt, Anu ^{[1
]}

Saaremaee, Merle ^{[1
]}

Saar, Tiiu ^{[2
]}

Boudinot, Sirje Rueuetel ^{[1
]}

机构：

[1] Tallinn Univ Technol, Dept Gene Technol, EE-12618 Tallinn, Estonia

[2] Estonian Univ Life Sci, Dept Infect Dis, EE-51014 Tartu, Estonia

[3] No Serv Hlth Board Estonia, EE-10617 Tallinn, Estonia

[4] Univ Tartu, Fac Med, EE-50411 Tartu, Estonia

来源：

PROCEEDINGS OF THE ESTONIAN ACADEMY OF SCIENCES | 2012年 / 61卷 / 04期

关键词：

influenza H1N1; human; porcine; ELISA; hemagglutination inhibition; EFFICACY; VACCINES;

D O I：

10.3176/proc.2012.4.07

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The H1N1 influenza strain Mexico 2009 (H1N1pandemic09) led to mild symptoms (with no or low fever) in Estonia during the 2009-2010 outbreak. Due to the lack of clinical signs, it was difficult to estimate the real spreading of this influenza virus in Estonia and no cases of H1N1 influenza were officially registered in animals either. We used an ELISA method to screen blood sample collections for the presence of anti-H1N1 and anti-H3N2 antibodies. All sera were also tested with the hemagglutination inhibition (HI) assay. Out of the 123 samples from human patients, 23 (i.e. 18.7%) were seropositive for the H1N1pandemic09 virus. In addition, blood samples from six persons were positive for both H1N1 and H3N2 viruses, while according to the data from the Estonian Health Board, people aged 15-65 had a general disease rate of around 3.9%. Almost all of the tested animals from two herds (out of four studied) were seropositive for H1N1pandemic09. The seven HA protein sequences isolated from Estonia were aligned with a consensus sequence of the pandemic H1N1 HA sequences from Mexico using ClustalW, and 12 amino acids substitutions were found.

引用

页码：320 / 329

页数：10

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