Assessment of exposure to ethanol vapors released during use of Alcohol-Based Hand Rubs by healthcare workers

被引:17
作者
Hautemaniere, Alexis [1 ,2 ]
Cunat, Lisiane [2 ]
Ahmed-Lecheheb, Djihane [2 ,3 ]
Hajjard, Farah [2 ]
Gerardin, Fabien [4 ]
Morele, Yves [4 ]
Hartemann, Philippe [1 ,2 ]
机构
[1] Univ Hosp Nancy, Infect Prevent & Control, Nancy, France
[2] Lorraine Univ, Fac Med Nancy, Dept Publ Hlth & Environm, SERES, Nancy, France
[3] Lorraine Univ, Fac Med Nancy, INSERM, Nutr Genet & Environm Risk Exposure U954, Nancy, France
[4] INRS, Dept Ingn Proc, Lab Proc & Epurat Polluants, Vandoeuvre Les Nancy, France
关键词
Ethanol; Alcohol-Based Hand Rub; Air exposure; Gas Chromatography; Photoionization detector; HYGIENE PRACTICE; ABSORPTION; PROGRAM; INTERVENTIONS; SANITIZER; ADHERENCE; SKIN;
D O I
10.1016/j.jiph.2012.09.015
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Background: Despite the increasing use of Alcohol-Based Hand Rub solutions, few studies have quantified the concentrations of inhaled ethanol. Objective: The aim of this study was to assess ethanol exposure during hygienic and surgical hand disinfection practices. Method: Ethanol concentrations were measured at the nose level of a wooden dummy and human volunteers. Two systems were used in parallel to determine short-term ethanol vapor exposures: activated charcoal tubes followed by gas chromatography analysis and direct reading on a photoionization detector (PID). Exposure was assessed for 4 different sequences (N = 10) reproducing hand rubs for simple surgery, nursing care, intensive care and surgical scrub. Results: The ethanol concentrations measured were of a similar order between the dummy and volunteers. The concentrations obtained by PID were higher than the gas chromatography values for the simple care (45%) and nursing care (27%) sequences and reflected specific exposure peaks of ethanol, whereas ethanol concentrations were continuously high for intensive care (440 mg m(-3)) or surgical scrub (650 mg m(-3)). Conclusion: Ethanol concentrations were similar for these two exposure assessment methods and demonstrated a relationship between handled doses and inhaled doses. However, the ethanol vapors released during hand disinfection were safe for the healthcare workers. (C) 2012 King Saud Bin Abdulaziz University for Health Sciences. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:16 / 26
页数:11
相关论文
共 38 条
[1]  
[Anonymous], FICH 017 METR ALC ET
[2]   HYDRATION AND PERCUTANEOUS-ABSORPTION .2. INFLUENCE OF HYDRATION ON WATER AND ALKANOL PERMEATION THROUGH SWISS MOUSE SKIN - COMPARISON WITH HAIRLESS MOUSE [J].
BEHL, CR ;
BARRETT, M .
JOURNAL OF PHARMACEUTICAL SCIENCES, 1981, 70 (11) :1212-1215
[3]   Dermal and pulmonary absorption of propan-1-ol and propan-2-ol from hand rubs [J].
Below, Harald ;
Partecke, Ivo ;
Huebner, Nils-Olaf ;
Bieber, Nora ;
Nicolai, Thomas ;
Usche, Alexander ;
Assadian, Ojan ;
Below, Elke ;
Kampf, Guenter ;
Parzefall, Wolfram ;
Heidecke, Claus-Dieter ;
Zuba, Dariusz ;
Bessonneau, Vincent ;
Kohlmann, Thomas ;
Kramer, Axel .
AMERICAN JOURNAL OF INFECTION CONTROL, 2012, 40 (03) :250-257
[4]   Assessment of Exposure to Alcohol Vapor from Alcohol-Based Hand Rubs [J].
Bessonneau, Vincent ;
Thomas, Olivier .
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 2012, 9 (03) :868-879
[5]  
Bismuth C, 2000, TOXICOLOGIE CLIN, P836
[6]  
BLANK IRVEST H., 1964, J INVEST DERMATOL, V43, P415, DOI 10.1038/jid.1964.174
[7]  
Bonnard N., 2011, FICHE TOXICOLOGIQUE
[8]  
Bowers RV, 1942, Q J STUD ALCOHOL, V3, P31
[9]   Guideline for hand hygiene in health-care settings - Recommendations of the Healthcare Infection Control Practices Advisory Committee and the HICPAC/SHEA/APIC/IDSA Hand Hygiene Task Force [J].
Boyce, JM ;
Pittet, D .
AMERICAN JOURNAL OF INFECTION CONTROL, 2002, 30 (08) :S1-S46
[10]   Can alcohol-based hand-rub solutions cause you to lose your driver's license? Comparative cutaneous absorption of various alcohols [J].
Brown, T. L. ;
Gamon, S. ;
Tester, P. ;
Martin, R. ;
Hosking, K. ;
Bowkett, G. C. ;
Gerostamoulos, D. ;
Grayson, M. L. .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2007, 51 (03) :1107-1108