Assessment of the reliability of the motor unit size index (MUSIX) in single subject "round-robin" and multi-centre settings

被引：13

作者：

Alix, James J. P. ^{[1
]}

Neuwirth, Christoph ^{[2
]}

Gelder, Lucy ^{[3
]}

Burkhardt, Christian ^{[2
]}

Castro, Jose ^{[4
]}

de Carvalho, Mamede ^{[4
]}

Gawel, Malgorzata ^{[5
]}

Goedee, Stephan ^{[6
]}

Grosskreutz, Julian ^{[7
]}

Lenglet, Timothee ^{[8
]}

Moglia, Cristina ^{[9
]}

Omer, Taha ^{[10
,11
]}

Schrooten, Maarten ^{[12
]}

Nandedkar, Sanjeev ^{[13
]}

Stalberg, Erik ^{[14
]}

Barkhaus, Paul E. ^{[15
,16
]}

Furtula, Jasna ^{[17
]}

van Dijk, Johannes P. ^{[18
]}

Baldinger, Reto ^{[2
]}

Costa, Joao ^{[4
]}

Otto, Marit ^{[17
]}

Sandberg, Arne ^{[14
]}

Weber, Markus ^{[2
]}

机构：

[1] Univ Sheffield, Sheffield Inst Translat Neurosci, 385A Glossop Rd, Sheffield S10 2HQ, S Yorkshire, England

[2] Kantonsspital, Neuromuscular Dis Unit ALS Clin, St Gallen, Switzerland

[3] Univ Sheffield, Stat Serv Unit, Sheffield, S Yorkshire, England

[4] Univ Lisbon, Hosp Santa Maria, Fac Med, Inst Med Mol,Dept Neurosci, Lisbon, Portugal

[5] Med Univ Warsaw, Dept Neurol, Warsaw, Poland

[6] UMC Utrecht, Dept Neurol & Neurosurg, Brain Ctr Rudolf Magnus, Utrecht, Netherlands

[7] Jena Univ Hosp, Hans Berger Dept Neurol, Jena, Germany

[8] Grp Hosp Pitie Salpetriere, APHP, Dept Neurophysiol, Paris, France

[9] Univ Torino, ALS Ctr Torino, Dept Neurosci Rita Levi Montalcini, Turin, Italy

[10] Biomed Sci Inst TBSI, Trinity Coll, Dublin, Ireland

[11] Beaumont Hosp, Dublin, Ireland

[12] Univ Hosp Leuven, Dept Neurol, Leuven, Belgium

[13] Natus Med Inc, 15 Dartantra Dr, Hopewell Jct, NY 12533 USA

[14] Uppsala Univ, Dept Neurosci, Clin Neurophysiol, Uppsala, Sweden

[15] Milwaukee Vet Adm, Med Ctr, Milwaukee, WI USA

[16] Med Coll Wisconsin, Milwaukee, WI 53226 USA

[17] Aarhus Univ Hosp, Dept Clin Neurophysiol, Aarhus, Denmark

[18] Univ Ulm, Dept Orthodont, Ulm, Germany

来源：

CLINICAL NEUROPHYSIOLOGY | 2019年 / 130卷 / 05期

关键词：

Motor unit number index; Motor unit size index; Motor unit; Motor neuron; Amyotrophic lateral sclerosis; Electrophysiology; NUMBER; MUNIX;

D O I：

10.1016/j.clinph.2019.01.020

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objective: The motor unit size index (MUSIX) is incorporated into the motor unit number index (MUNIX). Our objective was to assess the intra-/inter-rater reliability of MUSIX in healthy volunteers across single subject "round robin" and multi-centre settings. Methods: Data were obtained from (i) a round-robin assessment in which 12 raters (6 with prior experience and 6 without) assessed six muscles (abductor pollicis brevis, abductor digiti minimi, biceps brachii, tibialis anterior, extensor digitorum brevis and abductor hallucis) and (ii) a multi-centre study with 6 centres studying the same muscles in 66 healthy volunteers. Intrafinter-rater data were provided by 5 centres, 1 centre provided only intra-rater data. Intrafinter-rater variability was assessed using the coefficient of variation (COV), Bland-Altman plots, bias and 95% limits of agreement. Results: In the round-robin assessment intra-rater COVs for MUSIX ranged from 7.8% to 28.4%. Inter-rater variability was between 7.8% and 16.2%. Prior experience did not impact on MUSIX values. In the multi-centre study MUSIX was more consistent than the MUNIX. Abductor hallucis was the least reliable muscle. Conclusions: The MUSIX is a reliable neurophysiological biomarker of reinnervation. Significance: MUSIX could provide insights into the pathophysiology of a range of neuromuscular disorders, providing a quantitative biomarker of reinnervation. (C) 2019 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.

引用

页码：666 / 674

页数：9

共 18 条

[1] Motor unit number index (MUNIX) versus motor unit number estimation (MUNE): A direct comparison in a longitudinal study of ALS patients [J].

Boekestein, Werner A. ;

Schelhaas, Helenius J. ;

van Putten, Michel J. A. M. ;

Stegeman, Dick F. ;

Zwarts, Machiel J. ;

van Dijk, Johannes P. .

CLINICAL NEUROPHYSIOLOGY, 2012, 123 (08) :1644-1649

[2] Motor unit number index (MUNIX): Is it relevant in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP)? [J].

Delmont, Emilien ;

Benvenutto, Agnes ;

Grimaldi, Stephan ;

Duprat, Laureline ;

Philibert, Manon ;

Pouget, Jean ;

Grapperon, Aude-Marie ;

Salort-Campana, Emmanuelle ;

Sevy, Amandine ;

Verschueren, Annie ;

Attarian, Shahram .

CLINICAL NEUROPHYSIOLOGY, 2016, 127 (03) :1891-1894

[3] DETERMINANTS OF MEAN MOTOR UNIT SIZE - IMPACT ON ESTIMATES OF MOTOR UNIT NUMBER [J].

DOHERTY, TJ ;

STASHUK, DW ;

BROWN, WF .

MUSCLE & NERVE, 1993, 16 (12) :1326-1331

[4] MUNIX: Reproducibility and clinical correlations in Amyotrophic Lateral Sclerosis [J].

Escorcio-Bezerra, Marcio Luiz ;

Abrahao, Agessandro ;

de Castro, Isac ;

Troccoli Chieia, Marco Antonio ;

de Azevedo, Lyamara Apostolico ;

Pinheiro, Denise Spinola ;

de Oliveira Braga, Nadia Iandoli ;

Bulle de Oliveira, Acary Souza ;

Manzano, Gilberto Mastrocola .

CLINICAL NEUROPHYSIOLOGY, 2016, 127 (09) :2979-2984

[5] Adaptive and maladaptive motor axonal sprouting in aging and motoneuron disease [J].

Gordon, T ;

Hegedus, J ;

Tam, SL .

NEUROLOGICAL RESEARCH, 2004, 26 (02) :174-185

[6] ELECTROPHYSIOLOGICAL ESTIMATION OF NUMBER OF MOTOR UNITS WITHIN A HUMAN MUSCLE [J].

MCCOMAS, AJ ;

FAWCETT, PRW ;

CAMPBELL, MJ ;

SICA, REP .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1971, 34 (02) :121-&

[7] Contribution of reference electrode to the compound muscle action potential [J].

Nandedkar, Sanjeev D. ;

Barkhaus, Paul E. .

MUSCLE & NERVE, 2007, 36 (01) :87-92

[8] Motor unit number index: Guidelines for recording signals and their analysis [J].

Nandedkar, Sanjeev D. ;

Barkhaus, Paul E. ;

Stalberg, Erik V. ;

Neuwirth, Christoph ;

Weber, Markus .

MUSCLE & NERVE, 2018, 58 (03) :374-380

[9] MOTOR UNIT NUMBER INDEX (MUNIX): PRINCIPLE, METHOD, AND FINDINGS IN HEALTHY SUBJECTS AND IN PATIENTS WITH MOTOR NEURON DISEASE [J].

Nandedkar, Sanjeev D. ;

Barkhaus, Paul E. ;

Stalberg, Erik V. .

MUSCLE & NERVE, 2010, 42 (05) :798-807

[10] Motor unit number index (MUNIX) [J].

Nandedkar, SD ;

Nandedkar, DS ;

Barkhaus, PE ;

Stalberg, EV .

IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 2004, 51 (12) :2209-2211

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