Effect of Hypoxic-Ischemic Insults on the Composition of Fatty Acids in the Brain of Neonatal Rats

被引：10

作者：

Suganuma, Hiroki ^{[1
]}

Okumura, Akihisa ^{[1
]}

Kitamura, Yohei ^{[2
]}

Shoji, Hiromichi ^{[1
]}

Shimizu, Toshiaki ^{[1
]}

机构：

[1] Juntendo Univ, Fac Med, Dept Pediat, Tokyo 1138421, Japan

[2] Morinaga Milk Ind Co, Nutr Sci Inst, Zama, Kanagawa, Japan

来源：

ANNALS OF NUTRITION AND METABOLISM | 2013年 / 62卷 / 02期

关键词：

Docosahexaenoic acid; Fatty acid; Hypoxic-ischemic encephalopathy; Neonate; DOCOSAHEXAENOIC ACID; MATERNAL SUPPLEMENTATION; INFANT BRAIN; FETAL; PREGNANCY; PHOSPHOGLYCERIDES; DEFICIENCY; ACCRETION; DAMAGE; LIVER;

D O I：

10.1159/000346069

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Long-chain polyunsaturated fatty acids, especially docosahexaenoic acid (DHA; 22:6 n-3), comprise a major component of brain membrane phospholipids. The effect of neonatal hypoxic-ischennic insults on brain fatty acid composition is not completely understood. The aim of this study was to investigate alterations in brain fatty acid composition during development and in response to hypoxic-ischemic insults in neonatal rats. Methods: Postnatal day 7 pups were randomly assigned to two experimental groups: a control group or a hypoxic-ischemic group in which hypoxia-ischemia was produced by left common carotid artery occlusion and exposure to 8% oxygen for 1.5 h. Various brain fatty acids were measured on postnatal days 8, 10 and 14. Results: On postnatal day 14, the ratio of DHA to total fatty acids increased in the control group, but not in the hypoxic-ischemic group (p < 0.05). We observed no significant differences in arachidonic acid content in the brain between the two groups. Conclusions: These results suggest that hypoxic-ischemic insults interfere with accumulation of brain DHA in developing rats. DHA supplementation may be beneficial for treating neonatal hypoxic-ischemic encephalopathy. Copyright (C) 2013 S. Karger AG, Basel

引用

页码：123 / 128

页数：6

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