Evaluation of the hepatic and renal-protective effects of Ganoderma lucidum in mice

被引：47

作者：

Shieh, YH ^{[1
]}

Liu, CF ^{[1
]}

Huang, YK ^{[1
]}

Yang, JY ^{[1
]}

Wu, IL ^{[1
]}

Lin, CH ^{[1
]}

Lin, SC ^{[1
]}

机构：

[1] Taipei Med Univ, Dept Pharmacol, Taipei, Taiwan

来源：

AMERICAN JOURNAL OF CHINESE MEDICINE | 2001年 / 29卷 / 3-4期

关键词：

D O I：

10.1142/S0192415X01000526

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

The antioxidative effect of hot water extract of the mushroom Ganoderma lucidum on ethanol-induced free radical generation had been studied. In order to farther investigate the hepatic and renal protective mechanism of Ganoderma lucidum, rates of lipid peroxidation were determined. The hot water extract of Ganoderma lucidum dose-dependently exhibited antioxidative effect on mouse liver and kidney lipid peroxidation; our results indicated that hepatic and renal homogenates have a higher malonic dialdehyde level in an ethanol administered group than in the Ganoderma lucidum treated group. It was concluded that the hepatic and renal protective mechanism of Ganoderma lucidum, might be due at least in part to its prominent superoxide scavenging effect. Ganoderma extract could protect the liver and kidney from superoxide induced hepatic and renal damages.

引用

页码：501 / 507

页数：7

共 27 条

[1]

Bautista AP, 1999, FRONT BIOSCI, V4, P589

[2]

Jaya D. S., 1993, Indian Journal of Experimental Biology, V31, P453

[3]

KABIR Y, 1988, J NUTR SCI VITAMINOL, V34, P433, DOI 10.3177/jnsv.34.433

[4]

KERA Y, 1985, RES COMMUN CHEM PATH, V47, P203

[5]

Kim DH, 1999, BIOL PHARM BULL, V22, P162, DOI 10.1248/bpb.22.162

[6] In vitro chemopreventive effects of plant polysaccharides (Aloe barbadensis Miller, Lentinus edodes, Ganoderma lucidum and Coriolus versicolor) [J].

Kim, HS ;

Kacew, S ;

Lee, BM .

CARCINOGENESIS, 1999, 20 (08) :1637-1640

[7]

Kim KC, 1999, INT J MOL MED, V4, P273

[8] Antinociceptive components of Ganoderma lucidum [J].

Koyama, K ;

Imaizumi, T ;

Akiba, M ;

Kinoshita, K ;

Takahashi, L ;

Suzuki, A ;

Yano, S ;

Horie, S ;

Watanabe, K ;

Naoi, Y .

PLANTA MEDICA, 1997, 63 (03) :224-227

[9]

LEE SY, 1990, CHEM PHARM BULL, V38, P1359, DOI 10.1248/cpb.38.1359

[10] EVALUATION OF THE ANTIINFLAMMATORY AND LIVER-PROTECTIVE EFFECTS OF ANOECTOCHILUS-FORMOSANUS, GANODERMA-LUCIDUM AND GYNOSTEMMA-PENTAPHYLLUM IN RATS [J].

LIN, JM ;

LIN, CC ;

CHIU, HF ;

YANG, JJ ;

LEE, SG .

AMERICAN JOURNAL OF CHINESE MEDICINE, 1993, 21 (01) :59-69

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