Cytotoxic and antimalarial prenylated xanthones from Cratoxylum cochinchinense

被引:75
作者
Laphookhieo, Surat [1 ]
Syers, John Keith
Kiattansakul, Rattana
Chantrapromma, Kan
机构
[1] Mae Fah Luang Univ, Sch Sci, Chiang Rai 57100, Thailand
[2] Prince Songkla Univ, Fac Sci, Dept Chem, Hat Yai 90112, Thailand
[3] Walailak Univ, Sch Sci, Thasala 80160, Thailand
关键词
5-O-methylcelebixanthone; antimalarial activity; cytotoxic activity; Cratoxylum cochinchinense;
D O I
10.1248/cpb.54.745
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
A new prenylated xanthone, 5-O-methylcelebixanthone (1), together with six known compounds; celebixanthone (2), 1,3,7-trihydroxy-2,4-di(3-methylbut-2-enyl)xanthone (3), cochinchinone A (4), alpha-mangostin (5), beta-mangostin (6) and cochinchinone C (7) were isolated from roots of Cratoxylum cochinchinense. Their structures were elucidated by spectroscopic methods. Compounds 2 and 4-7 showed cytotoxic activity against the human lung cancer cell line (NCI-H187) with IC50 values ranging from 0.65 to 5.2 mu g/ml. Compounds 1, 2, 6 and 7 also showed antimalarial activity against Plasmodium falciparum with IC50 values of 3.2, 4.9, 7.2 and 2.6 mu g/ml, respectively.
引用
收藏
页码:745 / 747
页数:3
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