Up-regulation of D-3 dopamine receptor mRNA in the nucleus accumbens of human cocaine fatalities

被引：136
作者：
Segal, DM
Moraes, CT
Mash, DC
机构：
[1] UNIV MIAMI, SCH MED, DEPT NEUROL D4 5, MIAMI, FL 33101 USA
[2] UNIV MIAMI, SCH MED, DEPT MOL & CELLULAR PHARMACOL, MIAMI, FL 33101 USA
来源：
MOLECULAR BRAIN RESEARCH | 1997年 / 45卷 / 02期
关键词：
receptor; dopamine; reverse transcription; polymerase chain reaction; ribonuclease protection assay; cocaine; human brain; excited delirium;
D O I：
10.1016/S0169-328X(97)00025-9
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The effects of chronic cocaine use on D-3 receptor mRNA expression in the human nucleus accumbens was assessed by reverse transcription-polymerase chain reaction. D-3 receptor/cyclophilin mRNA ratios in the nucleus accumbens were increased 6-fold in cocaine overdose victims as compared to age-matched and drug-free control subjects. This finding demonstrates that chronic cocaine exposure leads to adaptive increases in the expression of D-3 receptor mRNA in a critical reward center in brain. (C) 1997 Elsevier Science B.V.
引用
收藏
页码：335 / 339
页数：5
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