Caesalpins A-H, Bioactive Cassane-Type Diterpenes from the Seeds of Caesalpinia minax

被引：42

作者：

Ma, Guoxu ^{[1
,2
]}

Yuan, Jingquan ^{[3
]}

Wu, Haifeng ^{[1
,2
]}

Cao, Li ^{[1
,2
]}

Zhang, Xiaopo ^{[1
,2
]}

Xu, Lijia ^{[1
,2
]}

Wei, Hua ^{[4
]}

Wu, Lizhen ^{[1
,2
]}

Zheng, Qingxia ^{[1
,2
]}

Li, Liyong ^{[1
,2
]}

Zhang, Lijing ^{[1
,2
]}

Yang, Junshan ^{[1
,2
]}

Xu, Xudong ^{[1
,2
]}

机构：

[1] Peking Union Med Coll, Key Lab Bioact Subst & Resource Utilizat Chinese, Minist Educ, Inst Med Plant Dev, Beijing 100193, Peoples R China

[2] Chinese Acad Med Sci, Beijing 100193, Peoples R China

[3] Natl Dev & Reform Commiss, Guangxi Bot Garden Med Plants, Natl Engn Lab Southwest Endangered Med Resource D, Nanning 530023, Peoples R China

[4] China Acad Chinese Med Sci, Inst Chinese Mat Med, Beijing 100700, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2013年 / 76卷 / 06期

基金：

中国国家自然科学基金;

关键词：

CIRCULAR-DICHROISM; CRISTA L; ALCOHOLS; BONDUC; STEM;

D O I：

10.1021/np300918q

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Eight new cassane-type diterpenes, caesalpins A-H (1-8), were isolated from the ethyl acetate extract of Caesalpinia minax. Compound 1 displayed significant antiproliferative activity against HepG-2 (IC50 4.7 mu M) and MCF-7 (IC50 2.1 mu M) cells, and compounds 2 and 4 exhibited selective cytotoxic activities against MCF-7 (IC50 7.9 mu M) and AGS (IC50 6.5 mu M) cells.

引用

页码：1025 / 1031

页数：7

共 22 条

[1]

BEECHAM AF, 1968, TETRAHEDRON LETT, P2355

[2] Antibacterial and antioxidant cassane diterpenoids from Caesalpinia benthamiana [J].

Dickson, Rita A. ;

Houghton, Peter J. ;

Hylands, Peter J. .

PHYTOCHEMISTRY, 2007, 68 (10) :1436-1441

[3]

Dimayuga RE, 2006, PLANTA MED, V72, P757

[4] [Rh2(OCOCF3)4] as an auxiliary chromophore in chiroptical studies on steroidal alcohols [J].

Frelek, J ;

Szczepek, WJ .

TETRAHEDRON-ASYMMETRY, 1999, 10 (08) :1507-1520

[5] CIRCULAR-DICHROISM .93. DETERMINATION OF THE ABSOLUTE-CONFIGURATION OF ALCOHOLS, OLEFINS, EPOXIDES, AND ETHERS FROM THE CD OF THEIR INSITU COMPLEXES WITH [RH2(O2CCF3)4] [J].

GERARDS, M ;

SNATZKE, G .

TETRAHEDRON-ASYMMETRY, 1990, 1 (04) :221-236

[6]

He S. Z., 2000, CHIN TRADIT HERB DRU, V31, P225

[7] Biodiversity conservation and drug discovery in Madagascar, part 32.: Antiproliferative cassane diterpenoids of Cordyla madagascariensis ssp madagascariensis from the Madagascar rainforest [J].

Hou, Yanpeng ;

Cao, Shugeng ;

Brodie, Peggy ;

Miller, James S. ;

Birkinshaw, Chris ;

Ratovoson, Fidisoa ;

Rakotondrajaona, Roland ;

Andriantsiferana, Rabodo ;

Rasamison, Vincent E. ;

Kingston, David G. I. .

JOURNAL OF NATURAL PRODUCTS, 2008, 71 (01) :150-152

[8]

Huang M. J., 2010, MOD CHIN MED, V12, P11

[9] Anthelmintic activity of Chenopodium album (L.) and Caesalpinia crista (L.) against trichostrongylid nematodes of sheep [J].

Jabbar, Abdul ;

Zaman, Muhammad Arfan ;

Iqbal, Zafar ;

Yaseen, Muhammad ;

Shamim, Asim .

JOURNAL OF ETHNOPHARMACOLOGY, 2007, 114 (01) :86-91

[10] Antimalarial activity of cassane- and norcassane-type diterpenes from Caesalpinia crista and their structure-activity relationship [J].

Kalauni, Surya Kant ;

Awale, Suresh ;

Tezuka, Yasuhiro ;

Banskota, Arjun Hari ;

Linn, Thein Zaw ;

Asih, Puji Budi Setia ;

Syafruddin, Din ;

Kadota, Shigetoshi .

BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2006, 29 (05) :1050-1052

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