Early and fatal immune haemolysis after so-called 'minor' ABO-incompatible peripheral blood stem cell allotransplantation

被引：56

作者：

OzielTaieb, S ^{[1
]}

FaucherBarbey, C ^{[1
]}

Chabannon, C ^{[1
]}

Ladaique, P ^{[1
]}

Saux, P ^{[1
]}

Gouin, F ^{[1
]}

Gastaut, JA ^{[1
]}

Maraninchi, D ^{[1
]}

Blaise, D ^{[1
]}

机构：

[1] CTR HOSP ST MARGUERITE,INTENS CARE UNIT,MARSEILLE,FRANCE

来源：

BONE MARROW TRANSPLANTATION | 1997年 / 19卷 / 11期

关键词：

ABO incompatibility; allogeneic peripheral blood stem cell transplantation;

D O I：

10.1038/sj.bmt.1700794

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

A 38-year-old man, blood group A+, was allotransplanted for multiple myeloma from his fully matched sister, blood group O+, Anti-A antibodies IgG and IgM titres of the donor were low, Allogeneic peripheral blood stem cells were harvested by leukapheresis after subcutaneous administration of G-CSF, Rapid engraftment occurred since 5.6 x 10(9)/l leukocytes were achieved on day +9 post-transplant. At this time a severe immune haemolytic syndrome occurred and direct antiglobulin test was positive (IgG and C3d), Elution showed an anti-A specificity, Evolution was rapidly unfavourable related to multiorgan failure, The patient died on day +20 post-transplant.

引用

页码：1155 / 1156

页数：2