Clozapine and obsessions in patients with recent-onset schizophrenia and other psychotic disorders

被引：77
作者：
de Haan, L [1 ]
Linszen, DH [1 ]
Gorsira, R [1 ]
机构：
[1] Univ Amsterdam, Dept Psychiat, Acad Med Ctr, Adolescentclin, NL-1100 DE Amsterdam, Netherlands
来源：
JOURNAL OF CLINICAL PSYCHIATRY | 1999年 / 60卷 / 06期
关键词：
D O I：
10.4088/JCP.v60n0603
中图分类号：
B849 [应用心理学];
学科分类号：
040203 ;
摘要：
Background: The increase or emergence of obsessions was compared in young patients with recent-onset schizophrenia or other psychotic disorders taking clozapine and other antipsychotic drugs. Method: We conducted a retrospective cohort study. Subjects were 121 consecutively admitted patients diagnosed with DSM-III-R schizophrenia, schizoaffective disorder, schizophreniform disorder, or psychotic disorder not otherwise specified. Obsessions were diagnosed according to DSM-IV criteria. Results: More clozapine-treated subjects (20.6%) than subjects treated with other antipsychotic drugs (1.3%) experienced an emergence or increase of obsessions (p < .01). Conclusion: Use of clozapine is associated with the emergence or increase of obsessions in early-phase schizophrenia.
引用
收藏
页码：364 / 365
页数：2
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