Cancer-associated fibroblast regulation of tumor neo-angiogenesis as a therapeutic target in cancer

被引：118
作者：
Wang, Fang-Tao [1 ]
Sun, Wei [2 ]
Zhang, Jing-Tao [1 ]
Fan, Yue-Zu [1 ]
机构：
[1] Tongji Univ, Sch Med, Tongji Hosp, Dept Surg, 389 Xincun Rd, Shanghai 200065, Peoples R China
[2] Tongji Univ, Shanghai Peoples Hosp 10, Sch Med, Dept Surg, Shanghai 200072, Peoples R China
来源：
ONCOLOGY LETTERS | 2019年 / 17卷 / 03期
基金：
中国国家自然科学基金;
关键词：
neoplasm; cancer-associated fibroblasts; tumor microenvironment; neo-angiogenesis; signaling pathway; target therapy; ENDOTHELIAL GROWTH-FACTOR; MEDIATED VASCULOGENIC MIMICRY; ACTIVATION PROTEIN-ALPHA; STROMAL FIBROBLASTS; CELL CARCINOMA; COLON-CANCER; TGF-BETA; VEGF-A; PODOPLANIN EXPRESSION; PROMOTE ANGIOGENESIS;
D O I：
10.3892/ol.2019.9973
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Adequate blood supply is essential for tumor survival, growth and metastasis. The tumor microenvironment (TME) is dynamic and complex, comprising cancer cells, cancer-associated stromal cells and their extracellular products. The TME serves an important role in tumor progression. Cancer-associated fibroblasts (CAFs) are the principal component of stromal cells within the TME, and contribute to tumor neo-angiogenesis by altering the proteome and degradome. The present paper reviews previous studies of the molecular signaling pathways by which CAFs promote tumor neo-angiogenesis and highlights therapeutic response targets. Also discussed are potential strategies for antitumor neo-angiogenesis to improve tumor treatment efficacy.
引用
收藏
页码：3055 / 3065
页数：11
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