5-lipoxygenase, leukotrienes biosynthesis and potential antileukotrienic agents

被引：42
作者：
Jampilek, J
Dolezal, M
Opletalova, V
Hartl, J
机构：
[1] Zentiva AS, Prague 10237, Czech Republic
[2] Charles Univ Prague, Dept Pharmaceut Chem & Drug Control, Prague, Czech Republic
[3] Fac Pharm Hradec Kralove, Hradec Kralove 50005, Czech Republic
来源：
CURRENT MEDICINAL CHEMISTRY | 2006年 / 13卷 / 02期
关键词：
5-lipoxygenase; FLAP; LTA(4)-hydrolase; leukotrienes; antileukotrienic agents;
D O I：
10.2174/092986706775197935
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Leukotrienes play an important role in the inflammatory process accompanying allergic diseases of respiratory, gastrointestinal and dermatological systems. Leukotrienes are generated from arachidonic acid as a result of the 5-lipoxygenase action. This paper deals with 5-lipoxygenase action mechanism and the following biosynthesis of all leukotrienes. In this article, potential anti leukotrienic agents are classified according to their mechanism of action. The original antileukotrienic compounds of the Research Institute for Pharmacy and Biochemistry in Prague (VUFB), Czech Republic are presented in a separate chapter of the paper.
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收藏
页码：117 / 129
页数：13
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