Docetaxel-loaded thermoresponsive conjugated linoleic acid-incorporated poloxamer hydrogel for the suppression of peritoneal metastasis of gastric cancer

被引：65

作者：

Bae, Woo Kyun ^{[1
]}

Park, Myong Suk ^{[1
]}

Lee, Ji Hee ^{[1
]}

Hwang, Jun Eul ^{[1
]}

Shim, Hyun Jeong ^{[1
]}

Cho, Sang Hee ^{[1
]}

Kim, Dae-Eun ^{[1
]}

Ko, Hyang Mi ^{[2
]}

Cho, Chong-Su ^{[5
,6
]}

Park, In-Kyu ^{[3
,4
]}

Chung, Ik-Joo ^{[1
,4
]}

机构：

[1] Chonnam Natl Univ, Hwasun Hosp, Dept Hematol Oncol, Jeollanamdo, South Korea

[2] Univ Toronto, Dept Lab Med & Pathol, Toronto, ON M5S 1A1, Canada

[3] Chonnam Natl Univ, Sch Med, Dept Biomed Sci, Res Inst Med Sci, Kwangju, South Korea

[4] Chonnam Natl Univ, Ctr Biomed Human Resources, Brain Korea Project 21, Kwangju, South Korea

[5] Seoul Natl Univ, Dept Agr Biotechnol, Seoul 151921, South Korea

[6] Seoul Natl Univ, Res Inst Agr & Life Sci, Seoul 151921, South Korea

来源：

BIOMATERIALS | 2013年 / 34卷 / 04期

关键词：

Thermoresponsive; Hydrogel; Docetaxel; Peritoneal metastasis model; Gastric cancer; PLURONIC P85; CELLS; CARCINOMATOSIS; FORMULATIONS; MODELS; CAVITY; DRUGS;

D O I：

10.1016/j.biomaterials.2012.10.077

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

We evaluated the potential of a thermoresponsive hydrogel consisting of conjugated linoleic acid-coupled Pluronic F-127 (Plu-CLA) as a controlled release, intraperitoneal delivery system for docetaxel with the aim of treating peritoneal dissemination of gastric cancer. Previously, we established a peritoneal metastasis model that involves the injection of BALB/c mice with TMK1 human gastric cancer cells. One week after the TMK1 cells were injected, the mice were injected intraperitoneally with docetaxel alone or docetaxel-loaded Plu-CLA. Tumor progression and response to therapy were monitored by micro-positron emission tomography. The total number of peritoneal tumors and the ascites volume were also measured. Compared with docetaxel alone, the combination of docetaxel and Plu-CLA (docetaxel-Plu-CLA) significantly and synergistically reduced tumor cell survival. Docetaxel-Plu-CLA showed excellent anti-tumor activity, inducing apoptosis more potently than docetaxel alone. Docetaxel-Plu-CLA also significantly reduced the number of peritoneal metastatic nodules and increased survival in the peritoneal gastric cancer xenograft model. Our results show that intraperitoneal administration of docetaxel-Plu-CLA synergistically inhibits peritoneal metastasis and prolongs survival in a peritoneal gastric cancer model. Therefore, Plu-CLA is a potential intraperitoneal-route carrier for hydrophobic docetaxel for the effective treatment of peritoneal metastatic gastric cancer. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：1433 / 1441

页数：9

共 25 条

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