Mediterranean nutraceutical foods: Strategy to improve vascular ageing

被引：24

作者：

Accardi, Giulia ^{[1
,2
]}

Aiello, Anna ^{[1
,2
]}

Gambino, Caterina Maria ^{[1
,2
]}

Virruso, Claudia ^{[1
,2
]}

Caruso, Calogero ^{[1
,2
]}

Candore, Giuseppina ^{[1
,2
]}

机构：

[1] Univ Palermo, Dept Pathobiol & Med Biotechnol, Corso Tukory 211, I-90134 Palermo, Italy

[2] Univ Palermo, Dept Pathobiol & Med Biotechnol, Corso Tukory 211, I-90134 Palermo, Italy

来源：

MECHANISMS OF AGEING AND DEVELOPMENT | 2016年 / 159卷

关键词：

Vascular ageing; Endothelial progenitor cells; Inflammageing; Nutraceuticals; ENDOTHELIAL PROGENITOR CELLS; BLOOD MONONUCLEAR-CELLS; DIETARY-PROTEIN SOURCES; KAPPA-B ACTIVATION; VIRGIN OLIVE OIL; INFLAMMATION; EXPRESSION; ANTIOXIDANTS; DYSFUNCTION; POLYPHENOLS;

D O I：

10.1016/j.mad.2016.02.007

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Ageing is characterized by a decline in all systemic functions. A greater susceptibility to apoptosis and senescence may contribute to proliferative and functional impairment of endothelial progenitor cells. They play an important role in neo-angiogenesis and endothelial repair. Vascular ageing is associated with changes in the structure and functions of vessels' wall. There are many possible causes of this damage. For sure, inflammation and oxidative stress play a fundamental role in the pathogenesis of endothelial dysfunction, commonly attributed to a reduced availability of nitric oxide. Inflammageing, the chronic low-grade inflammation that characterizes elderly people, aggravates vascular pathology and provokes atherosclerosis, the major cardiovascular disease. Nutraceutical and molecular biology represent new insights in this field. In fact, the first could represent a possible treatment in the prevention or delay of vascular ageing; the second could offer new possible targets for potential therapeutic interventions. In this review, we pay attention on the causes of vascular ageing and on the effects of nutraceuticals on it. (C) 2016 Elsevier Ireland Ltd. All rights reserved.

引用

页码：63 / 70

页数：8

共 78 条

[21] Endothelial progenitor cell-derived microvesicles activate an angiogenic program in endothelial cells by a horizontal transfer of mRNA [J].