Mediterranean nutraceutical foods: Strategy to improve vascular ageing

被引：24
作者：
Accardi, Giulia [1 ,2 ]
Aiello, Anna [1 ,2 ]
Gambino, Caterina Maria [1 ,2 ]
Virruso, Claudia [1 ,2 ]
Caruso, Calogero [1 ,2 ]
Candore, Giuseppina [1 ,2 ]
机构：
[1] Univ Palermo, Dept Pathobiol & Med Biotechnol, Corso Tukory 211, I-90134 Palermo, Italy
[2] Univ Palermo, Dept Pathobiol & Med Biotechnol, Corso Tukory 211, I-90134 Palermo, Italy
来源：
MECHANISMS OF AGEING AND DEVELOPMENT | 2016年 / 159卷
关键词：
Vascular ageing; Endothelial progenitor cells; Inflammageing; Nutraceuticals; ENDOTHELIAL PROGENITOR CELLS; BLOOD MONONUCLEAR-CELLS; DIETARY-PROTEIN SOURCES; KAPPA-B ACTIVATION; VIRGIN OLIVE OIL; INFLAMMATION; EXPRESSION; ANTIOXIDANTS; DYSFUNCTION; POLYPHENOLS;
D O I：
10.1016/j.mad.2016.02.007
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Ageing is characterized by a decline in all systemic functions. A greater susceptibility to apoptosis and senescence may contribute to proliferative and functional impairment of endothelial progenitor cells. They play an important role in neo-angiogenesis and endothelial repair. Vascular ageing is associated with changes in the structure and functions of vessels' wall. There are many possible causes of this damage. For sure, inflammation and oxidative stress play a fundamental role in the pathogenesis of endothelial dysfunction, commonly attributed to a reduced availability of nitric oxide. Inflammageing, the chronic low-grade inflammation that characterizes elderly people, aggravates vascular pathology and provokes atherosclerosis, the major cardiovascular disease. Nutraceutical and molecular biology represent new insights in this field. In fact, the first could represent a possible treatment in the prevention or delay of vascular ageing; the second could offer new possible targets for potential therapeutic interventions. In this review, we pay attention on the causes of vascular ageing and on the effects of nutraceuticals on it. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：63 / 70
页数：8
相关论文
共 78 条
[1]  
Accardi G., 2016, IMMUN AGEIN IN PRESS
[2]   Essential role of endothelial nitric oxide synthase for mobilization of stem and progenitor cells [J].
Aicher, A ;
Heeschen, C ;
Mildner-Rihm, C ;
Urbich, C ;
Ihling, C ;
Technau-Ihling, K ;
Zeiher, AM ;
Dimmeler, S .
NATURE MEDICINE, 2003, 9 (11) :1370-1376
[3]   What olive oil for healthy ageing? [J].
Aiello, Anna ;
Guccione, Giovanni Dara ;
Accardi, Giulia ;
Caruso, Calogero .
MATURITAS, 2015, 80 (02) :117-118
[4]   Red wine polyphenolics reduce the expression of inflammation markers in human colon-derived CCD-18Co myofibroblast cells: Potential role of microRNA-126 [J].
Angel-Morales, Gabriela ;
Noratto, Giuliana ;
Mertens-Talcott, Susanne .
FOOD & FUNCTION, 2012, 3 (07) :745-752
[5]   Hydroxytyrosol induces antioxidant/detoxificant enzymes and Nrf2 translocation via extracellular regulated kinases and phosphatidylinositol-3-kinase/protein kinase B pathways in HepG2 cells [J].
Angeles Martin, Maria ;
Ramos, Sonia ;
Belen Granado-Serrano, Ana ;
Rodriguez-Ramiro, Ildefonso ;
Trujillo, Mariana ;
Bravo, Laura ;
Goya, Luis .
MOLECULAR NUTRITION & FOOD RESEARCH, 2010, 54 (07) :956-966
[6]   Are Endothelial Progenitor Cells the Real Solution for Cardiovascular Diseases? Focus on Controversies and Perspectives [J].
Balistreri, Carmela R. ;
Buffa, Silvio ;
Pisano, Calogera ;
Lio, Domenico ;
Ruvolo, Giovanni ;
Mazzesi, Giuseppe .
BIOMED RESEARCH INTERNATIONAL, 2015, 2015
[7]   Phytochemistry - Ibuprofen-like activity in extra-virgin olive oil [J].
Beauchamp, GK ;
Keast, RSJ ;
Morel, D ;
Lin, JM ;
Pika, J ;
Han, Q ;
Lee, CH ;
Smith, AB ;
Breslin, PAS .
NATURE, 2005, 437 (7055) :45-46
[8]   Change in saturated fat intake is associated with progression of carotid and femoral intima-media thickness, and with levels of soluble intercellular adhesion molecule-1 [J].
Bemelmans, WJE ;
Lefrandt, JD ;
Feskens, EJM ;
Broer, J ;
Tervaert, JWC ;
May, JF ;
Smit, AJ .
ATHEROSCLEROSIS, 2002, 163 (01) :113-120
[9]   Dietary Protein Sources and the Risk of Stroke in Men and Women [J].
Bernstein, Adam M. ;
Pan, An ;
Rexrode, Kathryn M. ;
Stampfer, Meir ;
Hu, Frank B. ;
Mozaffarian, Dariush ;
Willett, Walter C. .
STROKE, 2012, 43 (03) :637-+
[10]   Major Dietary Protein Sources and Risk of Coronary Heart Disease in Women [J].
Bernstein, Adam M. ;
Sun, Qi ;
Hu, Frank B. ;
Stampfer, Meir J. ;
Manson, JoAnn E. ;
Willett, Walter C. .
CIRCULATION, 2010, 122 (09) :876-883
12345678