Temperature-Switched Binding of a RuII(dppz)/DNA Light-Switch Complex

被引：33

作者：

Walker, Michael G. ^{[1
]}

Gonzalez, Veronica ^{[1
,2
]}

Chekmeneva, Elena ^{[1
]}

Thomas, Jim A. ^{[1
]}

机构：

[1] Univ Sheffield, Dept Chem, Sheffield S3 7HF, S Yorkshire, England

[2] Univ Cardiff, Sch Chem, Cardiff, S Glam, Wales

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 48期

基金：

英国工程与自然科学研究理事会; 英国生物技术与生命科学研究理事会;

关键词：

calorimetry; DNA binding; light-switch effect; luminescence; ruthenium; RUTHENIUM DIPYRIDOPHENAZINE COMPLEX; TRANSITION-METAL-COMPLEXES; DNA-BINDING; DEOXYRIBONUCLEIC-ACID; INTERCALATION; RECOGNITION; PROTEIN; DUPLEX; LIGAND; MODES;

D O I：

10.1002/anie.201206260

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Cool to switch on: Although a Ru(dppz)-based complex binds to the grooves of duplex DNA at room temperature and above, it intercalates into duplex DNA at 10 °C, thus displaying a light-switch effect (see picture, dppz=dipyridylphenazine). Furthermore, once intercalated at low temperatures, emission does not disappear, even after the bound complex is warmed up to 35°C for several hours. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：12107 / 12110

页数：4

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