Cytotoxic triterpenoids from Lysimachia parvifolia

被引：9

作者：

He, Zhengchun ^{[1
,2
]}

Liang, Fengjie ^{[1
]}

Lu, Jing ^{[1
]}

Pan, Yuanjiang ^{[1
]}

机构：

[1] Zhejiang Univ, Dept Chem, Hangzhou 310027, Zhejiang, Peoples R China

[2] Dali Coll, Dept Pharm, Dali 671000, Peoples R China

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2013年 / 67卷

关键词：

Triterpenoid; Cytotoxic activity; Lysimachia parvifolia; ANAGALLIS-ARVENSIS; SAPONINS; CAPILLIPES; GLYCOSIDES;

D O I：

10.1016/j.ejmech.2013.06.043

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Five new oleanane-type triterpenoids, including two aglycones, 13 beta-28-epoxy-3 beta,22 alpha,23-trihydroxyolean-16-one (1) and 13 beta-28-epoxy-22 alpha,23-dihydroxyolean-3,16-dione (2), and three glycosides, anagalligenone-3-O-alpha-L-arabinopyranoside (3), anagalligenone-3-O-[beta-D-glucopyranosyl(1 -> 4)-alpha-L-arabinopyranoside] (4) and anagalligenone-3-O-[beta-D-xylopyranosyl(1 -> 2)-beta-D-glucopyranosyl(1 -> 4)-alpha-L-arabinopyranoside] (5), were isolated from the aerial parts of Lysimachia parvifolia, together with three known oleanane-type triterpenoid glycosides (6-8). The structures of the new compounds were subsequently elucidated by spectroscopic analysis and their cytotoxicities evaluated against six human cancer cell lines. Compounds 5-8 exhibited significant cytotoxicities against all the cell lines tested, with IC50 values lower than 10 mu M. The possible mechanism of action of compound 6 was also studied. (C) 2013 Elsevier Masson SAS. All rights reserved.

引用

页码：390 / 397

页数：8

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