A pH-Responsive System Based on Fluorescence Enhanced Gold Nanoparticles for Renal Targeting Drug Delivery and Fibrosis Therapy

被引：21

作者：

Lai, Xuandi ^{[1
]}

Geng, Xinran ^{[2
]}

Tan, Lishan ^{[1
]}

Hu, Jianqiang ^{[2
]}

Wang, Shubin ^{[1
]}

机构：

[1] Peking Univ, Shenzhen Peking Univ Hong Kong Univ Sci & Technol, Shenzhen Hosp, Dept Oncol,Shenzhen Key Lab Gastrointestinal Canc, 1120 Lianhua Rd, Shenzhen 518036, Peoples R China

[2] South China Univ Technol, Sch Chem & Chem Engn, Nanobiol Med Ctr, Key Lab Fuel Cell Technol Guangdong Prov, 381 Wushan Rd, Guangzhou 510640, Peoples R China

来源：

INTERNATIONAL JOURNAL OF NANOMEDICINE | 2020年 / 15卷

基金：

中国博士后科学基金;

关键词：

gold nanoparticles; self-assembly; pH sensitivity; drug delivery; renal fibrosis; IN-VIVO; COORDINATION;

D O I：

10.2147/IJN.S260069

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Background: Stimuli-responsive gold nano-assemblies have attracted attention as drug delivery systems in the biomedical field. However, there are challenges achieving targeted delivery and controllable drug release for specific diseases. Materials and Methods: In this study, a glutathione (GSH)-modified fluorescent gold nanoparticle termed AuLA-GSH was prepared and a Co2+-induced self-assembly drug delivery platform termed AuLA-GSH-Co was constructed. Both the pH-responsive character and drug loading behavior of AuLA-GSH-Co were studied in vitro. Kidney-targeting capability was investigated in vitro and in vivo. Finally, the anti-fibrosis efficiency of AuLA-GSH-Co in a mouse model of unilateral ureteral obstruction (UUO) was explored. Results: AuLA-GSH-Co was sensitive to pH changes and released Co2+ in acidic conditions, allowing it to have controllable drug release abilities. AuLA-GSH-Co was found to improve cellular uptake of Co2+ ions compared to CoCl2 in vitro. AuLA-GSH exhibited specific renal targeting and prolonged renal retention time with low non-specific accumulation in vivo. Moreover, the anti-fibrosis efficiency of AuLA-GSH-Co was higher compared to CoCl2 in a mouse model of unilateral ureteral obstruction (UUO). Conclusion: AuLA-GSH-Co could greatly enhance drug delivery efficiency with renal targeting capability and obviously relieve renal fibrosis, providing a promising strategy for renal fibrosis therapy.

引用

页码：5613 / 5627

页数：15

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