Cerebral Hyperperfusion Syndrome After Superficial Temporal Artery-middle Cerebral Artery Bypass for Severe Intracranial Steno-occlusive Disease: A Case Control Study

被引:11
作者
Teo, Kejia [1 ]
Choy, David K. S. [1 ]
Lwin, Sein [1 ]
Ning, Chou [1 ]
Yeo, Tseng Tsai [1 ]
Shen, Liang [2 ]
Chong, Vincent F. [3 ]
Teoh, Hock L. [2 ]
Seet, Raymond C. [2 ,4 ]
Chan, Bernard P. L. [2 ]
Sharma, Arvind K. [3 ]
Sharma, Vijay K. [2 ,4 ]
机构
[1] Natl Univ Singapore Hosp, Div Neurosurg, Singapore 119228, Singapore
[2] Natl Univ Singapore Hosp, Div Neurol, Singapore 119228, Singapore
[3] Natl Univ Singapore Hosp, Dept Diagnost Imaging, Singapore 119228, Singapore
[4] Natl Univ Singapore, Yong Loo Lin Sch Med, Singapore 117595, Singapore
关键词
Cerebral hyperperfusion syndrome; Extracranial-intracranial bypass; Intracranial stenosis; Superficial temporal artery-middle cerebral artery bypass; Single-photon emission computed tomography; Transcranial doppler; ROBIN-HOOD SYNDROME; TRANSCRANIAL DOPPLER; BLOOD-FLOW; INTRACEREBRAL HEMORRHAGE; ISCHEMIC-STROKE; RISK-FACTORS; ENDARTERECTOMY; CRITERIA; SURGERY;
D O I
10.1227/NEU.0b013e31828bb8b3
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
BACKGROUND: Intracranial stenoses carry increased risk for cerebral ischemia. We perform external carotid-internal carotid (EC-IC) artery bypass in our patients with severe stenosis of the intracranial internal carotid (ICA) or middle cerebral artery (MCA) with impaired cerebral vasodilatory reserve (CVR). OBJECTIVE: To evaluate cerebral hemodynamics and cerebral hyperperfusion syndrome (HPS) in patients who develop focal neurological deficits after EC-IC bypass surgery. METHODS: Patients with severe intracranial ICA or MCA stenosis and impaired CVR on transcranial Doppler (TCD) derived breath-holding index (BHI) were evaluated with acetazolamide-challenged technetium-99m hexamethylpropyleneamineoxime-single-photon emission computed tomography (SPECT). EC-IC bypass surgery was offered to patients with impaired CVR on SPECT. Close monitoring was performed in patients developing focal neurological deficits within 7 days of surgery. RESULTS: Of 112 patients with severe intracranial ICA/MCA stenosis, 77 (69%) showed impaired CVR and 46 (41%) underwent EC-IC bypass. Transient neurological deficits within 7 days of surgery developed in 8 (17%). HPS was confirmed by CT perfusion and/or SPECT in 7 cases. A strong correlation was observed between HPS and preoperative TCD-BHI values (0%, 6.3%, and 41% in patients with BHI 0.3-0.69, 0-0.3 and,0, respectively; P = .012). HPS patients showed more than a 50% increase in MCA flow velocity on TCD (compared with preoperative values) on the operated side (63.3% vs 3.3% on control side, P < .001). Meticulous control of blood pressure and hydration led to rapid and complete resolution of neurological deficits in all cases. CONCLUSION: Symptomatic cerebral HPS is common in the early postoperative period after EC-IC bypass surgery. Early diagnosis and appropriate management might prevent the complications of this syndrome.
引用
收藏
页码:936 / 942
页数:7
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