Computer-Guided Total Synthesis of Natural Products. Recent Examples and Future Perspectives

被引：8
作者：
Della-Felice, Franco [1 ]
Pilli, Ronaldo A. [1 ]
Sarotti, Ariel M. [2 ]
机构：
[1] Univ Estadual Campinas, Inst Quim, CP 6154, BR-13084971 Campinas, SP, Brazil
[2] Univ Nacl Rosario, CONICET, Fac Ciencias Bioquim & Farmaceut, Inst Quim Rosario, Suipacha 531,S2002LRK, Rosario, Santa Fe, Argentina
来源：
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY | 2018年 / 29卷 / 05期
基金：
巴西圣保罗研究基金会;
关键词：
total synthesis; natural products; NMR calculations; computational chemistry; GIAO; COMPLEX ORGANIC-MOLECULES; C-13; CHEMICAL-SHIFTS; PROTON COUPLING-CONSTANTS; STRUCTURE REVISION; STRUCTURAL REVISION; STRUCTURE ELUCIDATION; RELATIVE CONFIGURATION; NMR-SPECTROSCOPY; DFT CALCULATIONS; RED ALGA;
D O I：
10.21577/0103-5053.20180027
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Quantum chemical calculations of nuclear magnetic resonance (NMR) shifts and coupling constants have been extensively employed in recent years mainly to facilitate structural elucidation of organic molecules. When the results of such calculations are used to determine the most likely structure of a natural product in advance, guiding the subsequent synthetic work, the term "computer-guided synthesis" could be coined. This review article describes the most relevant examples from recent literature, highlighting the scope and limitations of this merged computational/ experimental approach as well.
引用
收藏
页码：1041 / 1075
页数：35
相关论文
共 50 条
  • [21] Recent advances in total synthesis of natural products by masked ortho-benzoquinones
    Chen, Chih-Ming
    Hsieh, Hsing-Pang
    JOURNAL OF THE CHINESE CHEMICAL SOCIETY, 2022, 69 (08) : 1210 - 1222
  • [22] Green extraction of natural products. Origins, current status, and future challenges
    Chemat, Farid
    Abert-Vian, Maryline
    Fabiano-Tixier, Anne Sylvie
    Strube, Jochen
    Uhlenbrock, Lukas
    Gunjevic, Veronika
    Cravotto, Giancarlo
    TRAC-TRENDS IN ANALYTICAL CHEMISTRY, 2019, 118 : 248 - 263
  • [23] Applications of Mitsunobu Reaction in total synthesis of natural products
    Heravi, Majid M.
    Ghalavand, Nastaran
    Ghanbarian, Manizheh
    Mohammadkhani, Leyla
    APPLIED ORGANOMETALLIC CHEMISTRY, 2018, 32 (09)
  • [24] Lessons from Total Synthesis of Hybrid Natural Products
    Suzuki, Keisuke
    CHEMICAL RECORD, 2010, 10 (05) : 291 - 307
  • [25] Applications of Flow Chemistry in Total Synthesis of Natural Products
    Majhi, Sasadhar
    CURRENT ORGANIC CHEMISTRY, 2023, 27 (12) : 1072 - 1089
  • [26] Total Synthesis of Natural Products Containing the Tetralone Subunit
    Thorat, Sagar S.
    Sibi, Mukund P.
    ARKIVOC, 2024,
  • [27] The Total Synthesis of Diquinane-Containing Natural Products
    Li, Huilin
    Zhang, Jing
    She, Xuegong
    CHEMISTRY-A EUROPEAN JOURNAL, 2021, 27 (15) : 4839 - 4858
  • [28] Furan Oxidation Reactions in the Total Synthesis of Natural Products
    Makarov, Anton S.
    Uchuskin, Maxim G.
    Trushkov, Igor V.
    SYNTHESIS-STUTTGART, 2018, 50 (16): : 3059 - 3086
  • [29] Biomimetic Total Synthesis of the Spiroindimicin Family of Natural Products
    Zheng, Xikang
    Li, Yan
    Guan, Mengtie
    Wang, Lingyue
    Wei, Shilong
    Li, Yi-Cheng
    Chang, Chin-Yuan
    Xu, Zhengren
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2022, 61 (38)
  • [30] Total Synthesis of Natural Antifouling Products
    Umezawa, Taiki
    Nishikawa, Keisuke
    Okino, Tatsufumi
    Matsuda, Fuyuhiko
    JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN, 2016, 74 (07) : 689 - 699
12345