Biophysical changes induced by xenon on phospholipid bilayers

被引:50
作者
Booker, Ryan D. [1 ]
Sum, Amadeu K. [1 ]
机构
[1] Colorado Sch Mines, Dept Chem & Biol Engn, Golden, CO 80401 USA
来源
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES | 2013年 / 1828卷 / 05期
关键词
General anesthesia; Lipid membrane; Phase transition; Simulation; Molecular dynamics; MOLECULAR-DYNAMICS SIMULATIONS; LATERAL PRESSURE PROFILES; ION-CHANNEL FUNCTION; D-ASPARTATE RECEPTOR; PARTICLE MESH EWALD; LIPID-BILAYER; NITROUS-OXIDE; PHASE-TRANSITIONS; PROTEIN FUNCTION; ANESTHETICS;
D O I
10.1016/j.bbamem.2013.01.016
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Structural and dynamic changes in cell membrane properties induced by xenon, a volatile anesthetic molecule, may affect the function of membrane-mediated proteins, providing a hypothesis for the mechanism of general anesthetic action. Here, we use molecular dynamics simulation and differential scanning calorimetry to examine the biophysical and thermodynamic effects of xenon on model lipid membranes. Our results indicate that xenon atoms preferentially localize in the hydrophobic core of the lipid bilayer, inducing substantial increases in the area per lipid and bilayer thickness. Xenon depresses the membrane gel-liquid crystalline phase transition temperature, increasing membrane fluidity and lipid head group spacing, while inducing net local ordering effects in a small region of the lipid carbon tails and modulating the bilayer lateral pressure profile. Our results are consistent with a role for nonspecific, lipid bilayer-mediated mechanisms in producing xenon's general anesthetic action. (C) 2013 Elsevier B.V. All rights reserved.
引用
收藏
页码:1347 / 1356
页数:10
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