Theranostics Based on Magnetic Nanoparticles and Polymers: Intelligent Design for Efficient Diagnostics and Therapy

被引：27

作者：

Gauger, Andrew J. ^{[1
]}

Hershberger, Kian K. ^{[1
]}

Bronstein, Lyudmila M. ^{[1
,2
,3
]}

机构：

[1] Indiana Univ, Dept Chem, Bloomington, IN 47405 USA

[2] King Abdulaziz Univ, Fac Sci, Dept Phys, Jeddah, Saudi Arabia

[3] Russian Acad Sci, AN Nesmeyanov Inst Organoelement Cpds, Moscow, Russia

来源：

FRONTIERS IN CHEMISTRY | 2020年 / 8卷

关键词：

theranostics; magnetic nanoparticles; polymer; engineering design; functionalization for cell targeting; DRUG-DELIVERY; MICELLES; MRI; NANOCARRIERS; COPOLYMERS;

D O I：

10.3389/fchem.2020.00561

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Theranostics is a fast-growing field due to demands for new, efficient therapeutics which could be precisely delivered to the target site using multimodal imaging with enhancing auxiliary actions. In this review article we discuss theranostic nanoplatforms containing polymers and magnetic nanoparticles along with other components. Magnetic nanoparticles allow for both diagnostic and therapeutic (hyperthermia) capabilities, while polymers can be reservoirs for drugs and are easily functionalized for cell targeting. We focus on the most important design strategies to achieve optimal theranostic effects as well as the roles of different components included in theranostics, reviewing the literature from the last 5 years.

引用

页数：7

共 47 条

[1] Polymer coated gold-ferric oxide superparamagnetic nanoparticles for theranostic applications [J].

Abedin, Muhammad Raisul ;

Umapathi, Siddesh ;

Mahendrakar, Harika ;

Laemthong, Tunyaboon ;

Coleman, Holly ;

Muchangi, Denise ;

Santra, Santimukul ;

Nath, Manashi ;

Barua, Sutapa .

JOURNAL OF NANOBIOTECHNOLOGY, 2018, 16

[2] Bio-inspired encapsulation and functionalization of iron oxide nanoparticles for biomedical applications [J].

Aisida, Samson O. ;

Akpa, Paul A. ;

Ahmad, Ishaq ;

Zhao, Ting-kai ;

Maaza, M. ;

Ezema, Fabian, I .

EUROPEAN POLYMER JOURNAL, 2020, 122

[3]

[Anonymous], J NANOMED NANOTECHNO

[4] A review of clinical photoacoustic imaging: Current and future trends [J].

Attia, Amalina Binte Ebrahim ;

Balasundaram, Ghayathri ;

Moothanchery, Mohesh ;

Dinish, U. S. ;

Bi, Renzhe ;

Ntziachristos, Vasilis ;

Olivo, Malini .

PHOTOACOUSTICS, 2019, 16

[5] Stealth magnetic nanocarriers of siRNA as platform for breast cancer theranostics [J].

Bruniaux, J. ;

Ben Djemaa, S. ;

Herve-Aubert, K. ;

Marchais, H. ;

Chourpa, I. ;

David, S. .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2017, 532 (02) :660-668

[6] Nanoparticle Beacons: Supersensitive Smart Materials with On/Off-Switchable Affinity to Biomedical Targets [J].

Cherkasov, Vladimir R. ;

Mochalova, Elizaveta N. ;

Babenyshev, Andrey V. ;

Vasilyeva, Alexandra V. ;

Nikitin, Petr I. ;

Nikitin, Maxim P. .

ACS NANO, 2020, 14 (02) :1792-1803

[7] Theranostic α-Lactalbumin-Polymer-Based Nanocomposite as a Drug Delivery Carrier for Cancer Therapy [J].

Delavari, Behdad ;

Bigdeli, Bahareh ;

Mamashli, Fatemeh ;

Gholami, Mandi ;

Bazri, Behrouz ;

Khoobi, Mehdi ;

Ghasemi, Atiyeh ;

Baharifar, Hadi ;

Dehghani, Sadegh ;

Gholibegloo, Elham ;

Arnani, Amir ;

Riahi-Alam, Nader ;

Ahmadian, Shahin ;

Goliaei, Bahram ;

Asli, Naisana S. ;

Rezayan, Ali Hossein ;

Saboury, Ali Akbar ;

Varamin, Pegah .

ACS BIOMATERIALS SCIENCE & ENGINEERING, 2019, 5 (10) :5189-5208

[8] Targeted Bifunctional Proteins and Hybrid Nanoconstructs for Cancer Diagnostics and Therapies [J].

Deyev, S. M. ;

Lebedenko, E. N. .

MOLECULAR BIOLOGY, 2017, 51 (06) :788-803

[9] Synthesis and functionalization of protease-activated nanoparticles with tissue plasminogen activator peptides as targeting moiety and diagnostic tool for pancreatic cancer [J].

Dobiasch, Sophie ;

Szanyi, Szilard ;

Kjaev, Aleko ;

Werner, Jens ;

Strauss, Albert ;

Weis, Christian ;

Grenacher, Lars ;

Kapilov-Buchman, Katya ;

Israel, Liron-Limor ;

Lellouche, Jean-Paul ;

Locatelli, Erica ;

Comes Franchini, Mauro ;

Vandooren, Jennifer ;

Opdenakker, Ghislain ;

Felix, Klaus .

JOURNAL OF NANOBIOTECHNOLOGY, 2016, 14

[10] Tailored ultra-small Prussian blue-based nanoparticles for MRI imaging and combined photothermal/photoacoustic theranostics [J].

Fetiveau, Lucile ;

Paul, Gabriella ;

Nicolas-Boluda, Alba ;

Volatron, Jeanne ;

George, Riya ;

Laurent, Sophie ;

Muller, Robert ;

Sancey, Lucie ;

Mejanelle, Philippe ;

Gloter, Alexandre ;

Gazeau, Florence ;

Catala, Laure .

CHEMICAL COMMUNICATIONS, 2019, 55 (98) :14844-14847

← 1 2 3 4 5 →