The biological role of actinin-4 (ACTN4) in malignant phenotypes of cancer

被引：84

作者：

Honda, Kazufumi ^{[1
,2
]}

机构：

[1] Natl Canc Ctr, Dept Chemotherapy & Clin Res, Chuo Ku, Tokyo 1040045, Japan

[2] Japan Agcy Med Res & Dev, AMED CREST AMED, Chiyoda Ku, Tokyo 1000004, Japan

来源：

CELL AND BIOSCIENCE | 2015年 / 5卷

关键词：

Cancer invasion; Metastasis; Actinin-4 (ACTN4); Actin-bundling protein; Biomarker; CELL-ADHESION SYSTEM; MUSCLE ALPHA-ACTININ; COPY NUMBER INCREASE; NF-KAPPA-B; OVARIAN-CANCER; GENE AMPLIFICATION; E-CADHERIN; PROGNOSTIC INDICATOR; PANCREATIC-CANCER; ESTROGEN-RECEPTOR;

D O I：

10.1186/s13578-015-0031-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Invasion and metastasis are malignant phenotypes in cancer that lead to patient death. Cell motility is involved in these processes. In 1998, we identified overexpression of the actin-bundling protein actinin-4 in several types of cancer. Protein expression of actinin-4 is closely associated with the invasive phenotypes of cancers. Actinin-4 is predominantly expressed in the cellular protrusions that stimulate the invasive phenotype in cancer cells and is essential for formation of cellular protrusions such as filopodia and lamellipodia. ACTN4 (gene name encoding actinin-4 protein) is located on human chromosome 19q. ACTN4 amplification is frequently observed in patients with carcinomas of the pancreas, ovary, lung, and salivary gland, and patients with ACTN4 amplifications have worse outcomes than patients without amplification. In addition, nuclear distribution of actinin-4 is frequently observed in small cell lung, breast, and ovarian cancer. Actinin-4, when expressed in cancer cell nuclei, functions as a transcriptional co-activator. In this review, we summarize recent developments regarding the biological roles of actinin-4 in cancer invasion.

引用

页数：9

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