Western blot analysis as an aid for the diagnosis of cutaneous leishmaniasis due to Leishmania major

被引：12

作者：

Pomares, Christelle ^{[1
,2
]}

Despierres, Laura ^{[1
]}

del Giudice, Pascal ^{[3
]}

Delaunay, Pascal ^{[1
,2
]}

Michel, Gregory ^{[2
]}

Ferrua, Bernard ^{[2
]}

Marty, Pierre ^{[1
,2
]}

机构：

[1] Univ Nice Sophia Antipolis, Ctr Hosp Univ Nice, Serv Parasitol Mycol, Fac Med, Nice, France

[2] Batiment Univ Archimed, INSERM, U895, F-06204 Nice 3, France

[3] Ctr Hosp, Serv Derrnatol & Infectiol, Frejus, France

来源：

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE | 2012年 / 106卷 / 07期

关键词：

Cutaneous leishmaniasis; Leishmania major; Serodiagnosis; Western blot; ANTIGENS; INFANTUM;

D O I：

10.1016/j.trstmh.2012.03.001

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Cutaneous leishmaniasis (CL) due to Leishmania major is endemic in the Old World. To evaluate the diagnostic value of Western blot (WB) compared with IFAT, we tested serum samples from 45 patients with proven CL Twenty-one (47%) patients were positive by IFAT and all patients were positive by WB with specific bands against 14 kDa and/or 18 kDa Leishmania antigens. Our results suggest that WB could be a useful non-invasive tool for the diagnosis of CL caused by L. major. (C) 2012 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved.

引用

页码：452 / 454

页数：3

共 5 条

[1] Cutaneous leishmaniasis: advances in disease pathogenesis, diagnostics and therapeutics
Ameen, M.
[J]. CLINICAL AND EXPERIMENTAL DERMATOLOGY, 2010, 35 (07) : 699 - 705
[2] Evaluation of antigens from various Leishmania species in a western blot for diagnosis of American tegumentary leishmaniasis
Gonçalves, CCM
Reiche, EMV
De Abreu, BA
Silveira, TGV
Felizardo, TC
Maia, KR
Costacurta, R
Padovesi, EJ
Dias, BP
Jankevicius, SI
Jankevicius, JV
[J]. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2002, 66 (01) : 91 - 102
[3] Detection by Western blot of four antigens characterizing acute clinical leishmaniasis due to Leishmania infantum
Marty, P
Lelievre, A
Quaranta, JF
Suffia, I
Eulalio, M
GariToussaint, M
LeFichoux, Y
Kubar, J
[J]. TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1995, 89 (06) : 690 - 691
[4] WESTERN-BLOT-ANALYSIS OF ANTIBODIES TO LEISHMANIA-INFANTUM ANTIGENS - POTENTIAL OF THE 14-KD AND 16-KD ANTIGENS FOR DIAGNOSIS AND EPIDEMIOLOGIC PURPOSES
MARY, C
LAMOUROUX, D
DUNAN, S
QUILICI, M
[J]. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1992, 47 (06) : 764 - 771
[5] Serodiagnosis of anthroponotic cutaneous leishmaniasis (ACL) caused by Leishmania tropica in Sanliurfa province, Turkey, where ACL is highly endemic
Zeyrek, Fadile Yidiz
Korkmaz, Metin
Oezbel, Yusuf
[J]. CLINICAL AND VACCINE IMMUNOLOGY, 2007, 14 (11) : 1409 - 1415

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