RITUXIMAB EXPERIENCE FROM A SINGLE CENTRE FOR PATIENTS WITH RHEUMATOID ARTHRITIS-RELATED INTERSTITIAL LUNG DISEASE

被引:2
作者
Eroglu, Didem Sahin [1 ]
Colaklar, Anil [2 ]
Baysal, Serdar [3 ]
Torgutalp, Murat [1 ,4 ]
Baygul, Asaf [5 ]
Yayla, Mucteba Enes [1 ]
Sezer, Serdar [1 ]
Uzun, Caglar [2 ]
Kumbasar, Ozlem Ozdemir [5 ]
Turgay, Tahsin Murat [1 ]
Kinikli, Gulay [1 ]
Ates, Askin [1 ]
机构
[1] Ankara Univ, Dept Internal Med, Div Rheumatol, Fac Med, Ankara, Turkey
[2] Ankara Univ, Dept Radiol, Fac Med, Ankara, Turkey
[3] Ankara Univ, Dept Internal Med, Fac Med, Ankara, Turkey
[4] Charite Univ Med Berlin, Nutr Med, Dept Gastroenterol Infectiol & Rheumatol, Berlin, Germany
[5] Ankara Univ, Dept Pulmononol, Fac Med, Ankara, Turkey
关键词
Rheumatoid arthritis; interstitial lung disease; progression; rituximab; AMERICAN-COLLEGE; RISK-FACTORS; PROGRESSION; CLASSIFICATION; GUIDELINE; COHORT;
D O I
10.36141/svdld.v39i3.12337
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
Objective. To demonstrate the effects of rituximab (RTX) in patients with rheumatoid arthritis-related interstitial lung disease (RA-ILD). Methods. A total of 165 patients who used RTX for the management of rheumatoid arthritis were retrospectively scrutinised. Among these, 26 patients diagnosed with RA-ILD were analysed (61.5% male, mean age at RTX infusion 61.4 +/- 6.5 years). To evaluate the efficacy of RTX on lung response, patients with pulmonary function test results and/or thorax computed tomography (chest-CT) of pre- and post-RTX were compared. Disease progression was defined as either a decline of >= 10% in forced vital capacity (FVC) and/or a decline of >= 15% in diffusion capacity of carbon monoxide (DLCO), or an increase of parenchymal involvement on chest-CT images according to the radiologists' assessment. Results. Among 26 patients, the most common radiologic pattern was usual interstitial pneumonia (42.3%), followed by non-specific interstitial pneumonia (38.5%). Data for lung response was available in 20 patients. Median pre- and post- RTX DLCO values were 71.0% (60.0-77.0) and 63.0% (47.0-74.0), respectively (p= 0.06). Median pre- and post-RTX FVC values were 74.0% (61.0-99.0) and 84.0% (63.0-100.0), respectively (p= 0.28). Overall, stabilization or regression of RA-ILD was provided in 13 (65.0%) patients, whereas 7 patients had progressive RA-ILD. Post-RTX, 5 patients were diagnosed with RA-ILD. Conclusion. Our results suggest that RTX is effective in achieving stabilization or even improvement of RA-ILD. However, considering that it does not cause regression in every patient and some develop RA-ILD under RTX, we still need more effective treatment options.
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