Inflammation and emotion regulation: Findings from the MIDUS II study

被引:3
作者
Ospina, Luz H. [1 ]
-Felts, Katie Beck [1 ]
Ifrah, Chloe [1 ]
Lister, Amanda [1 ]
Messer, Sylvie [1 ]
Russo, Scott J. [1 ]
Gross, James J. [2 ]
Kimhy, David [1 ,3 ,4 ]
机构
[1] Icahn Sch Med Mt Sinai, Dept Psychiat, New York, NY USA
[2] Stanford Univ, Dept Psychol, Stanford, CA USA
[3] James J Peters VA Med Ctr, MIRECC, Bronx, NY USA
[4] Icahn Sch Med Mt Sinai, Dept Psychiat & Neurosci, One Gustave L Levy Pl Box 1230, New York, NY 10029 USA
关键词
Inflammation; TNF-Alpha; Emotion regulation; Suppression; Reappraisal; MIDUS II; REGULATION STRATEGIES; DIVERGENT ASSOCIATIONS; INDIVIDUAL-DIFFERENCES; DISEASE; MODEL;
D O I
10.1016/j.bbih.2022.100536
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Emotion regulation (ER) strategies are thought to contribute to mental as well as physical health outcomes. Two common ER strategies include expressive suppression, or inhibition of emotional expression, and cognitive reappraisal, which involves changing how to think about an emotion-eliciting event in order to change its emotional impact. Recent reports have hypothesized that one potential way in which ER may be linked to health outcomes is via the immune system. However, information on this putative link is scarce. The present study aims to explore whether peripheral inflammatory biomarkers are associated with individual differences in ER-strategy use. Participants (n = 117) from the Midlife in the United States II (MIDUS II) study completed the Emotion Regulation Questionnaire (ERQ), and provided a blood sample for immune biomarker extraction including interleukin (IL)-6, IL-8, IL-10, tumor necrosis factor-& alpha; (TNF-& alpha;), C-reactive protein (CRP), E-selectin, Intercellular Adhesion Molecule-1 (ICAM-1), and fibrinogen. Results showed higher levels of expressive suppression were associated with decreased IL-10, TNF-& alpha;, and ICAM-1 levels (controlling for age, sex, BMI, total prescribed medications, and depressive symptoms). Consistent with these findings, hierarchical regression results identified TNF-& alpha; as a significant predictor of expressive suppression use. In contrast, no inflammatory markers were associated with predicted use of cognitive reappraisal. Our findings suggest a link between inflammation and specific ER-strategy use. Future research should consider the effects of pro-vs. anti-inflammatory cytokines on adaptive ER and subsequent mental and physical health.
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页数:6
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