Diagnostic value of brain MRI and 18F-FDG PET in the differentiation of parkinsonian type multiple system atrophy from Parkinson's disease

被引：25

作者：

Kwon, K. -Y. ^{[1
]}

Choi, C. G. ^{[2
]}

Kim, J. S. ^{[3
]}

Lee, M. C. ^{[1
]}

Chung, S. J. ^{[1
]}

机构：

[1] Ctr Parkinsonism & Other Movement Disorders, Dept Neurol, Seoul, South Korea

[2] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Radiol, Seoul 138736, South Korea

[3] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Nucl Med, Seoul 138736, South Korea

来源：

EUROPEAN JOURNAL OF NEUROLOGY | 2008年 / 15卷 / 10期

关键词：

(18)F-fluorodeoxyglucose positron emission tomography; magnetic resonance imaging; Parkinson's disease; parkinsonian type multiple system atrophy;

D O I：

10.1111/j.1468-1331.2008.02235.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background and purpose: Differentiation between parkinsonian type multiple system atrophy (MSA-P) and Parkinson's disease (PD) is important but often difficult. We investigated the diagnostic value of brain magnetic resonance imaging (MRI) and (18)F-fluorodeoxyglucose positron emission tomography ((18)F-FDG PET) in differentiating MSA-P from PD. Methods: Twenty-four patients with MSA-P (16 probable and 8 possible) and eight patients with PD were included in this study. Results: For analysis using the putaminal findings, the sensitivities were 58.3% by visual analysis of brain MRI, 95.8% by visual analysis of (18)F-FDG PET, and 79.2% by statistical parametric mapping (SPM) analysis of (18)F-FDG PET in differentiating MSA-P from PD; the specificity was 100% for each analysis. Using the putaminal findings, visual analysis of (18)F-FDG PET had a higher sensitivity compared with brain MRI (P = 0.004) and SPM analysis of (18)F-FDG PET revealed a tendency towards higher sensitivity compared with brain MRI (P = 0.063). For analysis using both putaminal and infratentorial findings, the sensitivities were 79.2% by visual analysis of brain MRI, 95.8% by visual analysis of (18)F-FDG PET, 95.8% by SPM analysis of (18)F-FDG PET in differentiating MSA-P from PD; the specificity was 100% for each analysis. Conclusion: Both brain MRI and (18)F-FDG PET showed diagnostic usefulness in differentiating MSA-P from PD, with (18)F-FDG PET being more sensitive than brain MRI.

引用

页码：1043 / 1049

页数：7

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