Mitochondrial spare respiratory capacity: Mechanisms, regulation, and significance in non-transformed and cancer cells

被引：209

作者：

Marchetti, Philippe ^{[1
,2
]}

Fovez, Quentin ^{[1
]}

Germain, Nicolas ^{[1
,2
]}

Khamari, Raeeka ^{[1
]}

Kluza, Jerome ^{[1
]}

机构：

[1] Univ Lille, Inst Rech Canc Lille, INSERM, CHU Lille,UMR9020 UMR S 1277 Canther,CNRS, 1 Pl Verdun, F-59045 Lille, France

[2] CHU Lille, Banque Tissus, Lille, France

来源：

FASEB JOURNAL | 2020年 / 34卷 / 10期

关键词：

mitochondrial adaptation; mitochondrial dysfunction; mitochondrial flexibility; mitochondrial metabolism; mitochondrial stress; oxygen consumption; respiratory reserve capacity; spare reserve capacity; uncoupling ratio; OXIDATIVE-PHOSPHORYLATION; DRUG-RESISTANCE; METABOLISM CONTRIBUTES; BIOENERGETIC FUNCTION; BCL-2; INHIBITION; RESERVE CAPACITY; PYRUVATE IMPORT; LUNG-CANCER; STRESS; TRANSPORT;

D O I：

10.1096/fj.202000767R

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mitochondrial metabolism must constantly adapt to stress conditions in order to maintain bioenergetic levels related to cellular functions. This absence of proper adaptation can be seen in a wide array of conditions, including cancer. Metabolic adaptation calls on mitochondrial function and draws on the mitochondrial reserve to meet increasing needs. Among mitochondrial respiratory parameters, the spare respiratory capacity (SRC) represents a particularly robust functional parameter to evaluate mitochondrial reserve. We provide an overview of potential SRC mechanisms and regulation with a focus on its particular significance in cancer cells.

引用

页码：13106 / 13124

页数：19

共 129 条

[1] Metabolic reprogramming during neuronal differentiation [J].

Agostini, M. ;

Romeo, F. ;

Inoue, S. ;

Niklison-Chirou, M. V. ;

Elia, A. J. ;

Dinsdale, D. ;

Morone, N. ;

Knight, R. A. ;

Mak, T. W. ;

Melino, G. .

CELL DEATH AND DIFFERENTIATION, 2016, 23 (09) :1502-1514

[2] Stress-Adaptive Response in Ovarian Cancer Drug Resistance: Role of TRAP1 in Oxidative Metabolism-Driven Inflammation [J].

Amoroso, Maria Rosaria ;

Matassa, Danilo Swann ;

Agliarulo, Ilenia ;

Avolio, Rosario ;

Maddalena, Francesca ;

Condelli, Valentina ;

Landriscina, Matteo ;

Esposito, Franca .

STRESS AND INFLAMMATION IN DISORDERS, 2017, 108 :163-198

[3]

Anso E, 2013, CANCER METAB, V1, DOI 10.1186/2049-3002-1-7

[4] Oxidative stress alters mitochondrial bioenergetics and modifies pancreatic cell death independently of cyclophilin D, resulting in an apoptosis-to-necrosis shift [J].

Armstrong, Jane A. ;

Cash, Nicole J. ;

Ouyang, Yulin ;

Morton, Jack C. ;

Chvanov, Michael ;

Latawiec, Diane ;

Awais, Muhammad ;

Tepikin, Alexei V. ;

Sutton, Robert ;

Criddle, David N. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2018, 293 (21) :8032-8047

[5] Mitochondrial pyruvate import is a metabolic vulnerability in androgen receptor-driven prostate cancer [J].

Bader, David A. ;

Hartig, Sean M. ;

Putluri, Vasanta ;

Foley, Christopher ;

Hamilton, Mark P. ;

Smith, Eric A. ;

Saha, Pradip K. ;

Panigrahi, Anil ;

Walker, Christopher ;

Zong, Lin ;

Martini-Stoica, Heidi ;

Chen, Rui ;

Rajapakshe, Kimal ;

Coarfa, Cristian ;

Sreekumar, Arun ;

Mitsiades, Nicholas ;

Bankson, James A. ;

Ittmann, Michael M. ;

O'Malley, Bert W. ;

Putluri, Nagireddy ;

McGuire, Sean E. .

NATURE METABOLISM, 2019, 1 (01) :70-85

[6] Towards the control of intracellular protein turnover:: Mitochondrial Lon protease inhibitors versus proteasome inhibitors [J].

Bayot, Aurelien ;

Basse, Nicolas ;

Lee, Irene ;

Gareil, Monique ;

Pirotte, Bernard ;

Bulteau, Anne-Laure ;

Friguet, Bertrand ;

Reboud-Ravaux, Michele .

BIOCHIMIE, 2008, 90 (02) :260-269

[7] NADPH Oxidase 4 (Nox4) Suppresses Mitochondrial Biogenesis and Bioenergetics in Lung Fibroblasts via a Nuclear Factor Erythroid-derived 2-like 2 (Nrf2)-dependent Pathway [J].

Bernard, Karen ;

Logsdon, Naomi J. ;

Miguel, Veronica ;

Benavides, Gloria A. ;

Zhang, Jianhua ;

Carter, A. Brent ;

Darley-Usmar, Victor M. ;

Thannickal, Victor J. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2017, 292 (07) :3029-3038

[8] Assessing mitochondrial dysfunction in cells [J].

Brand, Martin D. ;

Nicholls, David G. .

BIOCHEMICAL JOURNAL, 2011, 435 :297-312

[9] Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming [J].

Buck, Michael D. ;

O'Sullivan, David ;

Geltink, Ramon I. Klein ;

Curtis, Jonathan D. ;

Chang, Chih-Hao ;

Sanin, David E. ;

Qiu, Jing ;

Kretz, Oliver ;

Braas, Daniel ;

van der Windt, Gerritje J. W. ;

Chen, Qiongyu ;

Huang, Stanley Ching-Cheng ;

O'Neill, Christina M. ;

Edelson, Brian T. ;

Pearce, Edward J. ;

Sesaki, Hiromi ;

Huber, Tobias B. ;

Rambold, Angelika S. ;

Pearce, Erika L. .

CELL, 2016, 166 (01) :63-76

[10] Characterisation of an Isogenic Model of Cisplatin Resistance in Oesophageal Adenocarcinoma Cells [J].

Buckley, Amy M. ;

Bibby, Becky A. S. ;

Dunne, Margaret R. ;

Kennedy, Susan A. ;

Davern, Maria B. ;

Kennedy, Breandan N. ;

Maher, Stephen G. ;

O'Sullivan, Jacintha .

PHARMACEUTICALS, 2019, 12 (01)

← 1 2 3 4 5 6 7 8 9 10 →