Nuclear envelope rupture: Actin fibers are putting the squeeze on the nucleus

被引：40

作者：

Lammerding, Jan ^{[1
]}

Wolf, Katarina ^{[2
]}

机构：

[1] Cornell Univ, Weill Inst Cell & Mol Biol, Nancy E & Peter C Meinig Sch Biomed Engn, Ithaca, NY 14853 USA

[2] Radboud Univ Nijmegen, Med Ctr, Dept Cell Biol, NL-6525 GA Nijmegen, Netherlands

来源：

JOURNAL OF CELL BIOLOGY | 2016年 / 215卷 / 01期

基金：

美国国家科学基金会;

关键词：

CELL-MIGRATION; LAMINOPATHIES; DEFORMATION; COMPLEX;

D O I：

10.1083/jcb.201609102

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cells exhibit transient nuclear envelope ruptures during interphase, but the responsible biophysical processes remain unclear. In this issue, Hatch and Hetzer (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201603053) show that actin fibers constrict the nucleus, causing chromatin protrusions and nuclear membrane ruptures at sites with nuclear lamina defects.

引用

页码：5 / 8

页数：4

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