Microwave-Assisted Domino Benzannulation of a-Oxo Ketenes: Preparation of 1,3-Dihydro-2H-1,5-benzodiazepin-2-ones

被引：28

作者：

Castillo, Juan-Carlos ^{[2
]}

Presset, Marc ^{[1
]}

Abonia, Rodrigo ^{[2
]}

Coquerel, Yoann ^{[1
]}

Rodriguez, Jean ^{[1
]}

机构：

[1] Aix Marseille Univ, CNRS, Inst Sci Mol Marseille, iSm2,Ctr St Jerome,Serv 531, F-13397 Marseille 20, France

[2] Univ Valle, Dept Quim, Cali 25360, Colombia

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2012年 / 2012卷 / 12期

关键词：

Annulation; Diazo compounds; Microwave chemistry; Nitrogen heterocycles; Domino reactions; 1,3-DICARBONYL COMPOUNDS; WOLFF REARRANGEMENT; O-PHENYLENEDIAMINE; ORGANIC-SYNTHESIS; STEP ECONOMY; POT; 2-DIAZO-1,3-DIKETONES; 1,5-BENZODIAZEPINES; ACYLKETENES; ROUTE;

D O I：

10.1002/ejoc.201200093

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The microwave irradiation of a series of 2-diazo-1,3-diketones in the presence of an o-phenylenediamine derivative triggered a domino Wolff rearrangement/nucleophilic addition/intramolecular imination sequence to provide a new synthetic entry to 1,3-dihydr-2H-1,5-benzodiazepin-2-ones, a class of molecules with important biological properties.

引用

页码：2338 / 2345

页数：8

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