Responsiveness of Quantitative Cartilage Measures Over One Year in Knee Osteoarthritis: Comparison of Radiography and MRI Assessments

被引：7
作者：
Cromer, Megan S. [1 ,2 ]
Bourne, Roger M. [2 ]
Fransen, Marlene [3 ]
Fulton, Roger [2 ,4 ,5 ]
Wang, Shih-Chang [1 ,6 ]
机构：
[1] Westmead Hosp, Dept Radiol, Westmead, NSW 2145, Australia
[2] Univ Sydney, Fac Hlth Sci, Discipline Med Radiat Sci, Sydney, NSW 2006, Australia
[3] Univ Sydney, Fac Hlth Sci, Clin & Rehabil Sci Res Grp, Sydney, NSW 2006, Australia
[4] Westmead Hosp, Dept Med Phys, Westmead, NSW 2145, Australia
[5] Univ Sydney, Sch Phys, Sydney, NSW 2006, Australia
[6] Sydney Med Sch, Discipline Imaging, Sydney, NSW, Australia
来源：
JOURNAL OF MAGNETIC RESONANCE IMAGING | 2014年 / 39卷 / 01期
基金：
英国医学研究理事会;
关键词：
!text type='JS']JS[!/text]N; knee osteoarthritis; quantitative magnetic resonance imaging; cartilage thickness; JOINT SPACE WIDTH; ARTICULAR-CARTILAGE; REGIONAL-ANALYSIS; RESONANCE; PROGRESSION; PRECISION; ACCURACY; VOLUME; OA;
D O I：
10.1002/jmri.24141
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
PurposeTo directly compare the responsiveness of quantitative imaging measures of disease progression in knee osteoarthritis (OA). In the medial compartment of the knee comparison was made between: 1) radiographic joint space narrowing (JSN); 2) global quantitative magnetic resonance imaging (qMRI) of cartilage volume; 3) regional qMRI of cartilage thickness; and 4) regional analysis using an ordered value (OV) methodology. Materials and Methods3T MRI and weight-bearing radiography of the knees were performed at baseline and 1-year timepoints in 23 subjects (mean age 63 years) with symptomatic knee OA. Standardized response means (SRM) were calculated for each measure. Statistical analysis to determine significance of change between timepoints was performed with a two-tailed Student's t-test (JSN, global, regional analysis) and nonparametric Mann-Whitney test (ordered values). ResultsAt 1 year, global cartilage volume losses of 2.3% (SRM -0.44) in the medial tibia and 6.9% in the medial femur (SRM -0.74) were recorded. SRM for JSN was -0.46. Regional analysis revealed largest reductions in cartilage thickness in the external (SRM -0.84) weight-bearing subregion of the medial femur and in the posterior subregion of the medial tibia (SRM -0.79). OV analysis in the medial compartment revealed areas of cartilage thinning (four ranked OV) and cartilage thickening (two ranked OV). ConclusionThe MRI OV approach proved to be a superior analysis tool for detecting changes in cartilage morphology over a 1-year period. Radiographically defined JSN was found to be the least responsive measurement method of knee OA disease progression. J. Magn. Reson. Imaging 2014;39:103-109. (c) 2013 Wiley Periodicals, Inc.
引用
收藏
页码：103 / 109
页数：7
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