Membrane-anchored chemokine fusion proteins A novel class of adjuvants for immunotherapy

被引：5

作者：

Nelson, Peter J. ^{[1
]}

Muenchmeier, Niklas ^{[2
]}

机构：

[1] Univ Munich, Med Klin & Poliklin 4, AG Klin Biochem, Munich, Germany

[2] Scripps Res Inst, Inst Immunol & Microbial Sci, San Diego, CA USA

来源：

ONCOIMMUNOLOGY | 2013年 / 2卷 / 11期

关键词：

active immunotherapy; adoptive immunotherapy; cancer therapy; chemokine; endothelial anergy; GPI anchor; leukocyte recruitment; TUMOR ANGIOGENESIS; ENDOTHELIUM; ADHESION;

D O I：

10.4161/onci.26619

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Adoptive or active cancer immunotherapy can fail owing to the inefficient recruitment of effector leukocytes to malignant lesions. The intratumoral injection of recombinant proteins comprising a chemokine-derived domain linked to the mucin stalk of chemokine (C-X3-C motif) ligand 1 (CX3CL1) and a glycosylphosphatidylinositol anchor can specifically enhance the recruitment of effector cell subsets to solid tumors.

引用

页数：3