Membrane-anchored chemokine fusion proteins A novel class of adjuvants for immunotherapy

被引：5
|
作者：
Nelson, Peter J. [1 ]
Muenchmeier, Niklas [2 ]
机构：
[1] Univ Munich, Med Klin & Poliklin 4, AG Klin Biochem, Munich, Germany
[2] Scripps Res Inst, Inst Immunol & Microbial Sci, San Diego, CA USA
来源：
ONCOIMMUNOLOGY | 2013年 / 2卷 / 11期
关键词：
active immunotherapy; adoptive immunotherapy; cancer therapy; chemokine; endothelial anergy; GPI anchor; leukocyte recruitment; TUMOR ANGIOGENESIS; ENDOTHELIUM; ADHESION;
D O I：
10.4161/onci.26619
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Adoptive or active cancer immunotherapy can fail owing to the inefficient recruitment of effector leukocytes to malignant lesions. The intratumoral injection of recombinant proteins comprising a chemokine-derived domain linked to the mucin stalk of chemokine (C-X3-C motif) ligand 1 (CX3CL1) and a glycosylphosphatidylinositol anchor can specifically enhance the recruitment of effector cell subsets to solid tumors.
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页数：3
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