HER-2, Notch, and Breast Cancer Stem Cells: Targeting an Axis of Evil

被引：101
作者：
Korkaya, Hasan [1 ]
Wicha, Max S. [1 ]
机构：
[1] Univ Michigan, Ctr Comprehens Canc, Dept Internal Med Oncol, Ann Arbor, MI 48109 USA
来源：
CLINICAL CANCER RESEARCH | 2009年 / 15卷 / 06期
关键词：
RESISTANCE; TUMORS;
D O I：
10.1158/1078-0432.CCR-08-3087
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Increasing evidence indicates that tumor-initiating (cancer stem) cells may contribute to treatment resistance and relapse, suggesting that improved clinical outcome will require effective targeting of this cell population. Recent studies suggest that the remarkable clinical efficacy of trastuzumab may relate to its ability to target cancer stem cell populations.
引用
收藏
页码：1845 / 1847
页数：3
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