Heterochromatin: new possibilities for the inheritance of structure

被引：318
作者：
Grewal, SIS
Elgin, SC
机构：
[1] Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA
[2] Washington Univ, Dept Biol, St Louis, MO 63130 USA
来源：
CURRENT OPINION IN GENETICS & DEVELOPMENT | 2002年 / 12卷 / 02期
关键词：
D O I：
10.1016/S0959-437X(02)00284-8
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Significant portions of the eukaryotic genome are heterochromatic, made up largely of repetitious sequences and possessing a distinctive chromatin structure associated with gene silencing. New insights into the form of packaging, the associated histone modifications, and the associated nonhistone chromosomal proteins of heterochromatin have suggested a mechanism for providing an epigenetic mark that allows this distinctive chromatin structure to be maintained following replication and to spread within a given domain.
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页码：178 / 187
页数：10
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