The effects of an obesogenic diet during pregnancy on fetal growth and placental gene expression are gestation dependent

被引：31
作者：
King, V. [1 ]
Hibbert, N. [1 ]
Seckl, J. R. [2 ]
Norman, J. E. [1 ]
Drake, A. J. [2 ]
机构：
[1] Univ Edinburgh, MRC, Ctr Reprod Hlth, Queens Med Res Inst, Edinburgh EH16 4TJ, Midlothian, Scotland
[2] Univ Edinburgh, Queens Med Res Inst, Univ BHF Ctr Cardiovasc Sci, Endocrinol Unit, Edinburgh EH16 4TJ, Midlothian, Scotland
来源：
PLACENTA | 2013年 / 34卷 / 11期
关键词：
Obesity; Fetal growth; Placenta; MATERNAL OBESITY; MICE; MURINE; TRANSPORT; MODELS; MOUSE;
D O I：
10.1016/j.placenta.2013.09.006
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Exposure to overnutrition in utero may increase offspring cardiometabolic disease risk. A mouse model of maternal exposure to an obesogenic diet (DIO) was used to determine effects on fetal and placental weight and gene expression in mid- and late gestation. DIO altered placental gene expression in midgestation without differences in fetal or placental weights. Weight gain was attenuated in DIO dams in late gestation and male pup weight was reduced, however there were no persistent changes in placental gene expression. Differences in maternal weight gain and/or specific dietary components may impact on fetal and placental growth and later disease risk. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1087 / 1090
页数：4
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