Short total synthesis of (+)-madindolines A and B

被引：40

作者：

Hirose, T ^{[1
]}

Sunazuka, T

Shirahata, T

Yamamoto, D

Harigaya, Y

Kuwajima, I

Omura, S

机构：

[1] Kitasato Univ, Kitasato Inst, Minato Ku, Tokyo 1088642, Japan

[2] Kitasato Univ, Sch Pharmaceut Sci, Minato Ku, Tokyo 1088642, Japan

[3] Japan Sci & Technol Corp, JST, CREST, Minato Ku, Tokyo 1088642, Japan

来源：

ORGANIC LETTERS | 2002年 / 4卷 / 04期

关键词：

D O I：

10.1021/ol017058i

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A short and efficient total synthesis of (+)-madindolines A (1) and B (2), potent and selective inhibitors of interleukin 6, has been achieved. The synthesis features a key chelation-controlled 1,4-diastereoselective acylation to generate the quaternary carbon and an intramolecular acylation of allylsilane to build up the cyclopentene unit.

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收藏

页码：501 / 503

页数：3

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