An efficient method for the synthesis of 1,5-benzodiazepine derivatives under microwave irradiation without solvent

被引:163
作者
Pozarentzi, M [1 ]
Stephanidou-Stephanatou, J [1 ]
Tsoleridis, CA [1 ]
机构
[1] Aristotle Univ Thessaloniki, Dept Chem, Organ Chem Lab, GR-54006 Thessaloniki, Macedonia, Greece
关键词
benzodiazepines; o-phenylenediamines; microwave irradiation; green chemistry;
D O I
10.1016/S0040-4039(02)00115-6
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
2, 3-Dihydro-1H-1.5-benzodiazepines have been synthesized in solvent-free conditions from o-phenylenediamines and ketones in the presence of a catalytic amount of acetic acid, under microwave irradiation. This method is a very easy, rapid and high yielding reaction for the synthesis of 1,5-benzodiazepine derivatives. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:1755 / 1758
页数:4
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